Bone Abstracts

Collagen barrier membranes are used in guided tissue regeneration to support bone healing and periodontal regeneration. Pharmacological inhibitors of prolyl-hydroxylases (PHD) can support hard and soft tissue regeneration and are therefore a promising tool for periodontal therapy. Here we evaluate the release kinetic of the PHD inhibitors dimethyloxaloylglycine and L-mimosine from the collagen barrier membranes.The PHD inhibitors were lyophilized onto co...

After trauma or carious lesion dental pulp healing is difficult to predict. In addition systemic diseases like diabetes mellitus can impair the regenerative capacity. New regenerative strategies target prolyl hydroxylase (PHD) by pharmacological inhibitors to stimulate hard and soft tissue healing. PHD inhibitors such as L-mimosine (L-MIM) induce vascular endothelial growth factor (VEGF) production by promoting angiogenesis. However, it is unclear if L-MIM is a feasible tool t...

Success in periodontal regeneration through guided tissue regeneration relies on the healing capacity of the host tissue. Platelet preparations are mitogenic and stimulate regeneration through high growth factor levels. Here we assessed collagen barrier membranes (CBM) as carriers for the secretome of activated platelets. We evaluated cell-attachment, the release of the secretome, and cell proliferation.Secretome of washed platelets (washed PSEC) and unw...