Bone Abstracts

The biological relevance of Klotho in aging processes was impressively demonstrated in transgene and knock out mouse experiments and its impact on calcium, vitamin D and phosphate metabolism suggests multifunctional modes of action.The human alpha Klotho gene encodes two transcripts, one for a protein of 130 kDa with a short intracellular and a transmembrane region and the two extracellular domains KL1 and KL2. A second transcript exists due to alternati...