Bone Abstracts

Background: Relationships between muscle function and bone have been examined using a range of techniques, with conflicting results. We aimed to determine these associations within an adult population comprising individuals with high bone mass and family controls.Methods: Recruitment was from four UK sites within the high bone mass (HBM) study; cases and unaffected family controls were pooled. Peak ground reaction force and peak power, during a multiple ...

Sarcopenia and osteoporosis are common in later life, often coexist, and increase the risk of adverse health outcomes such as disability, falls and fracture. Binkley and colleagues recently devised a score-based system for the diagnosis of ‘dysmobility syndrome’ in an attempt to combine adverse musculoskeletal phenotypes and indentify older individuals at particular risk. We applied these criteria to a larger cohort of participants from the Hertfordshire Cohort Study...

Extreme high bone mass (HBM) may be monogenic (e.g. LRP5 mutations) or polygenic, due to variants in the same genes determining bone mineral density (BMD) as found in the general population. We aimed to determine how variation in established BMD loci, in different functional pathways, explains the HBM phenotype.241 unexplained HBM cases (lumbar spine(LS)1+total hip(TH) Z-scores≥+4.4) were recruited from 15 UK centres, by screening...

see PP31....

Extreme high bone mass (HBM) may be monogenic (e.g. due to mutations in SOST or LRP5) or polygenic, due to variants in the same genes determining bone mineral density (BMD) as found in the general population. We aimed to determine the genetic cause underlying HBM in an extreme HBM population.258 unexplained HBM cases (defined as L1 Z-score ≥+3.2 plus total hip Z-score ≥+1.2, or total hip Z-score ≥+3.2 and L1 <...

Patients with improved health understanding have greater autonomy over, and motivation towards, health-related lifestyles. We compared self-perceived fracture risk and 3-year incident fracture rates in postmenopausal women for a range of co-morbid diseases using data from the Global Longitudinal study of Osteoporosis in Women (GLOW).GLOW is an international cohort study involving 723 physician practices across 10 countries in Europe, North America, Austr...