Bone Abstracts

Introduction: Persistence is defined as the period between the start and the interruption of a pharmacological treatment. In osteoporotic patients, persistence to therapy is poor, resulting in reduced benefits and increased risk of fracture.The aim of this study is to analyze persistence with drug therapy in osteoporotic patients in the Campania region.Material and methods: We conducted a retrospective population-based cohort study to examine prescriptio...

Background: Among body composition phenotypes there is no consensus on definition and consequences of sarcopenic obese phenotype. The recommended method to quantify the muscle mass is the dual energy X-ray absorptiometry (DXA), based on measurement of total fat mass and appendicular lean mass. A high BMI may provide a great bone mineral density (BMD) in many individuals, but it does not guarantee optimal bone strength. The aim of our study is to investigate the influence of sa...

Background: Sarcopenic obesity is usually defined by the combination of sarcopenia and obesity but there is not a standard definition yet. The recommended method for the quantification of muscle mass is dual energy X-ray absorptiometry (DXA), based on assessment of total fat mass and appendicular lean mass. Low Body Mass Index (BMI) used to be considered as a risk factor for fragility fracture. However, recent evidences have demonstrated a correlation between BMI and vertebral...

see P260....

Background: Higher BMI values are associated with greater bone mineral density (BMD) resulting in a site-specific protective effect for fragility fractures. However, pathophysiologic influence of central adiposity on bone quality may oppose the seemingly positive influence of a greater mechanical loading with higher body masses. The objective of our study was to evaluate the impact of visceral fat on trabecular bone microarchitecture in postmenopausal obese women.<p class=...

Background: An inadequate intake of nutrients, low levels of physical activity, and chronic diseases contribute to reduce muscle mass and physical performance in elderly. WHO reported that number of individuals aged ≥60 years will triple in 2050, with the sub-population aged >85 years that will grow faster than the others. Market of nutraceuticals and dietary supplements is growing in Italy, in particular aimed to improve health in elderly. Objective of this scoping ...

Background: Post-menopausal women generally present reduced serum levels of vitamin D, reduced VDR expression in skeletal muscle cells, and a gradual loss of muscle mass and muscle function. The relationship between serum 25-hydroxyvitamin D [25(OH)D3] levels and muscle strength has been extensively investigated, even though there is no agreement in literature. Therefore, aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physica...

Background: Bone involvement in patients with β-thalassemia is well known, but only few studies have analyzed bone microarchitecture and the prevalence of intervertebral disc calcifications (IDCs) in these patients. The aim of our study was to evaluate the bone quality in a group of patients with β-thalassemia in terms of geometry and microarchitecture properties; moreover, we evaluated the presence of IDCs in these patients.Material and method...

Objective(s): We aimed to determine the impact of microgravity-induced osteoporosis on the future of space programs.Material and methods: We performed a metanalysis of the available literature, finding out different studies about i) muscle atrophy due to the absence of workload, which can consequently induce bone loss; ii) the effect of long term inactivity on bone mass; iii) the effect of calcium and vitamin D supplementation in women and men in order t...

Background: Osteoporosis treatment involves several therapeutic tools, including long-term drug therapy. Subjects with chronic disorders are more likely to be non-adherent and/or non-persistent to treatment than those with other diseases. Adherence is the extent to which patients take medication as prescribed by their physicians, whereas persistence is the time from treatment initiation to discontinuation. Lack of persistence is common among subjects using oral anti-osteoporot...