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ba0001pp409 | Osteoporosis: treatment | ECTS2013

25-OH vitamin D and γ-δ TCR lymphocyte interplay in the pathogenesis of acute phase reaction after zoledronic acid infusion for osteoporosis treatment

Crotti Chiara , Cavaciocchi Francesca , De Santis Maria , Ceribelli Angela , Fabbriciani Gianluigi , Selmi Carlo

Background: Zoledronic acid (ZA) for the treatment of osteoporosis (OP) is associated with a transient post-infusional acute phase reaction (APR) due to ZA-mediated activation of γ-δ TCR lymphocytes (γ-δTCR) and production of cytokines.Primary objective: To investigate if OP patients developing APR (APR+) after ZA infusion have lower 25-OH vitamin D (25-OHvD) levels and a higher percentage of γ-δTCR compared to patients with...

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ba0003pp296 | Osteoporosis: treatment | ECTS2014

Correlation between 25-OH vitamin D, γδTCR lymphocytes and acute phase reaction after the first zoledronic acid infusion for post-menopausal osteoporosis

Massarotti Marco S , Cavaciocchi Francesca , Crotti Chiara , Maria De Santis , Ceribelli Angela , Fabbriciani Gianluigi , Selmi Carlo

Background: Zoledronic acid (ZA) is associated with a transient post-infusional acute phase reaction (APR) due to the activation of γδTCR lymphocytes (γδTcells).Aims: To investigate if APR correlates with γδTcell percentage or cytokine polarization, or with 25-OH vitamin D levels; to identify a 25-OH vitamin D level associated with a lower risk of APR.Methods: Sera for ELISA test (IFNγ, IL17, and ...

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25-OH vitamin D and γ-δ TCR lymphocyte interplay in the pathogenesis of acute phase reaction after zoledronic acid infusion for osteoporosis treatment

Correlation between 25-OH vitamin D, γδTCR lymphocytes and acute phase reaction after the first zoledronic acid infusion for post-menopausal osteoporosis

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