Bone Abstracts

Collagen XV is a secreted proteoglycan localized in the outermost layer of the basement membrane and in the fibrillar matrix. Previously, the collagen XV gene (COL15A1) has been linked to osteogenic differentiation, being identified mainly in mature osteoblasts forming new bone tissue or lining bone trabeculae. Our previous data on collagen XV knockout fetuses reports subtle skeletal changes. The aim of this study was to analyse skeletal changes in adult mice lacking collagen ...

Collagen XIII is a conserved transmembrane collagen with wide distribution in various tissues. It can be enzymatically cleaved to form a soluble bioactive molecule with relevance to cell proliferation, migration and adhesion. Collagen XIII overexpression in mice causes a massive bone overgrowth with no defects in early skeletal development. The bone phenotype of Col13a1OE mice is most apparent in long tubular bones but also present in calvariae. Our findings show th...

Background: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and ultimately declining in bone biomechanical properties. Our main goal was to study the effects of the inflammatory process on the microarchitecture and mechanical properties of bone in the early stages of arthritis development.</p...