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ba0003pp110 | Cell biology: osteoblasts and bone formation | ECTS2014

Age-dependent loss of microvesicular galectin-3 and its consequences on bone formation in vitro and in vivo

Weilner Sylvia , Heimel Patrick , Keider Verena , Schraml Elisabeth , Weisz Florian , Chiang DML , Grillari-Voglauer Regina , Redl Heinz , Chen HY , Grillari Johannes

Introduction: Mesenchymal stem cells (MSCs) counteract the decline of physiologic functions but their regenerative power decreases with age. In particular osteogenic differentiation capacity of MSCs has been shown to decrease with age thereby contributing to slowed down bone formation and osteoporosis. While much is known about cellular aging of MSCs, little is known about extrinsic factors influencing their functionality. Here we set out to identify circulating factors of the...

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ba0003pp112 | Cell biology: osteoblasts and bone formation | ECTS2014

Levels of circulating vesicular microRNA-31 increase with age as well as in the case of osteoporosis and inhibit osteogenic differentiation capacity of mesenchymal stem cells

Weilner Sylvia , Schraml Elisabeth , Wassermann Klemens , Wieser Matthias , Messner Paul , Schneider Karl , Micutkova Lucia , Fortschegger Klaus , Maier Andrea B. , Westendorp Rudi , Resch Heinrich , Wolbank Susanne , Redl Heinz , Jansen-Durr Pidder , Pietschmann Peter , Grillari-Voglauer Regina , Grillari Johannes

Aging is a complex process that results in the decline of physiologic functions due to accumulation of damage in cells and tissues. Mesenchymal stem cells (MSCs) counteract this decline but their regeneration capacity decreases with age. In particular osteogenic differentiation potential of MSCs has been shown to decrease with age thereby contributing to slowed down bone formation and osteoporosis. While much is known about cellular aging of MSCs, little is known about factors...

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Bone Abstracts

Age-dependent loss of microvesicular galectin-3 and its consequences on bone formation in vitro and in vivo

Levels of circulating vesicular microRNA-31 increase with age as well as in the case of osteoporosis and inhibit osteogenic differentiation capacity of mesenchymal stem cells

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