Bone Abstracts

Objectives: Recent studies have demonstrated that vitamin K2 (VitK2) induces apoptosis of not only osteoclasts but also rheumatoid arthritis (RA) synovial cells in vitro, while its clinical effect on disease activity of RA remains unknown.Methods: 158 female RA patients (age 62.5 years, duration of disease 14.9 years) who had not been treated with warfarin, biologics, or teriparatide were enrolled in this study. VitK2 (45 mg/day) was administered orally ...

Objectives: Sox9 is a dominant but insufficient transcription factor to induce thorough primary chondrogenesis, so other factors which may induce primary chondrogenesis besides Sox9 have been assumed. The previously reported function of transcription factor Nkx3.2 is to maintain chondrogenic phenotype by suppressing Runx2, while recent studies demonstrated that mouse Nkx3.2 null mice shows severe metaphyseal dysplasia which is similar to that seen in type II collagen a1 (Col2a...

Objective: The purpose of this study is to investigate the effects of the combined teriparatide (TPTD) and denosumab (DMAB) on both cortical and cancellous bone regeneration.Materials and methods: Bone defects were created in the diaphysis of the right femur and in the epimetaphysis of the left femur in 8-week old female C57/BL6N mice. After making bone defects, Mice were given either saline or 40 μg/kg TPTD for 20 days (5× per week) and were s...