Bone Abstracts

MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as critical post-transcriptional regulators of gene expression. There is increasing evidence that miRNAs play an important role in osteoblast commitment and differentiation. The main aim of this study was to identify and characterize novel microRNAs regulating osteoblast functions. We report the role of mmu-miR-1187 in osteoblast differentiation and the mode by which it regulates osteogenesis. MicroRNA profiling of...

Bone regeneration and fracture healing processes are impaired in post menopausal osteoporosis which is induced by estrogen deficiency. Though agents like BMPs and PTH have been shown to promote bone regeneration but are associated with undesirable side effects. There is a need for new agents that enhance bone regeneration and repair.The aim of this study was to evaluate the bone regenerative capacity of medicarpin in the osteoporotic rat model. Cortical ...