Bone Abstracts

Introduction: Cardiovascular disease and osteoporosis have often been reported to coexist in older people. However, the literature is conflicting regarding size and indeed direction of the association. The aim of the present study was therefore to assess associations between the Framingham general cardiovascular risk score and bone characteristics in a cohort of older adults.Methods: We studied 374 men and 379 women, born 1931–1939, who participated...

Objectives: An increased fracture risk is reported in children requiring recurrent courses of glucocorticoids. Reduced bone mineral density (BMD), particularly in the trabecular compartment, has also been demonstrated in a number of childhood diseases treated with glucocorticoids. The differential contribution of glucocorticoids and underlying inflammatory disease to bone demineralisation is poorly understood. Childhood nephrotic syndrome (NS) often follows a relapsing-remitti...

Sarcopenia and osteoporosis are common in later life, often coexist, and increase the risk of adverse health outcomes such as disability, falls and fracture. Binkley and colleagues recently devised a score-based system for the diagnosis of ‘dysmobility syndrome’ in an attempt to combine adverse musculoskeletal phenotypes and indentify older individuals at particular risk. We applied these criteria to a larger cohort of participants from the Hertfordshire Cohort Study...

Introduction: Norway has one of the highest reported incidences of osteoporotic fracture. Since, bone mineral density (BMD) is a strong predictor of future fracture risk, high peak bone mass achievement is essential. This study is the first to examine BMD in a population-based study including Norwegian adolescents. Here we compare the measured BMD with international reference ranges and explore predictors of BMD in this population.Methods: In 2010–2...

Objective: Although metabolic syndrome is common in gout patients, recent reports that bone mineral density may actually be reduced (and falls common) in this group have led researchers to hypothesise that osteoporotic fracture may be more common in subjects with gout than in healthy controls. We tested this hypothesis in a national Danish registry.Material and Methods: We identified subjects as new users of allopurinol, a proxy for gout, for the years 1...

Although it has been suggested that overweight and obese children have an increased risk of fracture, recent studies in post-menopausal women have shown that the relationship between obesity and fracture risk varies by fracture site. Thus, obesity is protective against wrist fractures but confers an increased risk of humeral fractures. There are no data to suggest whether this observation is also present in children. We therefore assessed whether adiposity and overweight/obesi...

Maternal vitamin D status has been positively associated with infant bone mass in observational studies. We therefore evaluated whether 1000 IU/day cholecalciferol during pregnancy would lead to greater offspring bone mass at birth, in a UK, multicentre, randomised, double-blind, placebo-controlled trial (MAVIDOS, ISRCTN82927713).At 12 weeks’ gestation, pregnant women with a serum 25-hydroxyvitamin D [25(OH)D] 25-100 nmol/l were randomised to either...

Patients with improved health understanding have greater autonomy over, and motivation towards, health-related lifestyles. We compared self-perceived fracture risk and 3-year incident fracture rates in postmenopausal women for a range of co-morbid diseases using data from the Global Longitudinal study of Osteoporosis in Women (GLOW).GLOW is an international cohort study involving 723 physician practices across 10 countries in Europe, North America, Austr...