Bone Abstracts

During the differentiation of the osteoclast, it transform from a mono-nucleated cell to multinucleated cell by fusion of its precursors. Although, cell fusion is a complicated process which likely involves many regulating proteins, only a few osteoclast fusion regulating proteins were identified. We have identified dual-specificity tyrosine-phosphorylation regulated kinase 2 (Dyrk2) as a novel regulator of the osteoclast fusion process. Dyrk2 belongs to a family of protein ki...