Bone Abstracts

The ECTS and IOF have recently constructed a framework for the development of national guidelines for the management of glucocorticoid-induced osteoporosis in men and women aged 18 years and over in whom oral glucocorticoid therapy is considered for three months or longer. These review the epidemiology of GIO; assessment of risk utilises a fracture probability-based approach and intervention thresholds are based on 10 year probabilities using FRAX. National guidelines derived ...

The fundamental purpose of osteoporosis treatment is to reduce the risk of fracture. There is no validated quantitative marker that monitors risk reduction in the individual patient; available treatments are effective, but reduce fracture incidence only by 20–60%, and it is to be expected, therefore, that fractures will arise during treatment. The aim of treat-to-target strategies is to simplify management and ultimately reduce organ damage and improve clinical outcomes. ...

Oftenly, the question arises whether anti-osteoporotic drugs should be prescribed in glucocorticoid-treated premenopausal women. On the one hand, there are strong arguments to prescribe these drugs, when these patients are treated with high dose glucocorticoïds, and suffer from diseases that have a negative effect on bone, for instance SLE.On the other hand, the absolute fracture risk is low, related to their young age, and finally, in women with ch...

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The origin of the recent levelling-off in hip-fracture incidence in several settings is unknown.Methods: Using Danish national inpatient data for individuals aged ≥50 years during 1980–2010, we examined annual number and incidence of hip fractures and age, period, and cohort effects by log-likelihood estimates in Poisson regression models. Age adjustment was done by direct standardization, time-trend analysis by linear regression, and identifi...

Objective: The reasons for the recent decrease in hip fracture rates remain unclear. While current antiosteoporosis efforts are important also factors earlier in life seem essential and we examined age-period-cohort (APC) effects in hip fracture incidence in the Sweden (SE) and Denmark (DK).Material and Methods: We studied the entire populations aged ≧50 years from 1987 to 2010 in SE and DK and ascertained acute hip fractures in nationwide discharge r...

Objective: Over the last decade, there has been increasing scientific interest in vitamin D, and it is now advised that all pregnant women and infants should receive vitamin D supplementation. Despite of this, it is recognized that knowledge of vitamin D in the general public is limited. The internet is now an important source of health care information and analysis of internet search activity rates can provide information on disease epidemiology, health related behaviors and ...

Objective: Public Health England recommends that children in the United Kingdom (UK) aged over 1 year should take a vitamin D supplement containing 400 IU/day. Commercially available children’s multivitamin and vitamin D supplements were surveyed to determine the vitamin D content.Methods: Multivitamins and vitamin D supplements marketed at children <12 years and sold by nine UK supermarkets and health supplement retailers were surveyed. The vit...

Introduction: Cardiovascular disease and osteoporosis have often been reported to coexist in older people. However, the literature is conflicting regarding size and indeed direction of the association. The aim of the present study was therefore to assess associations between the Framingham general cardiovascular risk score and bone characteristics in a cohort of older adults.Methods: We studied 374 men and 379 women, born 1931–1939, who participated...

Objectives: An increased fracture risk is reported in children requiring recurrent courses of glucocorticoids. Reduced bone mineral density (BMD), particularly in the trabecular compartment, has also been demonstrated in a number of childhood diseases treated with glucocorticoids. The differential contribution of glucocorticoids and underlying inflammatory disease to bone demineralisation is poorly understood. Childhood nephrotic syndrome (NS) often follows a relapsing-remitti...