Bone Abstracts

To evaluate the regeneration of alveolar bone after treatment with bone-resorption inhibitors in old acyclic rats that had been through a long period of low estrogen. Thirty-two female Wistar rats with 20 months old intact and ovariectomized (OVX at 4 months of age), were randomized into four groups (n=8/group): i) intact; ii) OVX/O (corn oil); iii) OVX/E2 (17β-estradiol, 400 μg) and iv) OVX/RLX (Raloxifene, 1 mg/kg per day). All treatments began ...

Histomorphometry is often adopted as a methodological approach in research of femoral bone structure. However, it is common do not describe technical details of procedure especially on the steps of macroscopy, paraffin embedding and microtomy. So we propose a simplified, reliable and reproducible method of histological processing for intertrochanteric region and femoral neck of mice, to ensure the achievement of tissue sections with similar structures, cell populations and his...

The effects of neonatal thymectomy, at 3 days of age, on skeletal sexual dimorphism and bone quality during the development were examined in male and female Wistar rats. Rats were euthanized at 20, 40, or 120 postnatal days and femurs were collected. The Biomechanical compression test was used to evaluate bone breaking strength, energy-to-fracture, and extrinsic stiffness. During the prepubertal period, the neonatal thymectomy increases extrinsic stiffness of bone tissue signi...