ba0005oc4.5 | Catabolism and metabolism | ECTS2016
Pereira Marie
, Gohin Stephanie
, Cleasby Mark
, Chenu Chantal
Type 2 diabetes mellitus prevalence increases with age and the disease predisposes to increased risk of fractures and skeletal complications. One possible contributor to skeletal weakening in diabetes is a decline in blood supply. We hypothesised that bone blood flow is impaired in diabetic mice and that chronic administration of glucagon-like peptide-1 receptor agonists (GLP-1RA) can increase blood flow to bone, thereby stimulating bone formation and improving bone architectu...