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ba0003oc5.1 | Important pathways in bone biology and cancer | ECTS2014

In vivo efficacy of a pharmacological inhibitor of TNAP to prevent arterial calcification and its associated cardiac hypertrophy and mortality

Sheen Campbell , Chhea Thangchanthida , Pinkerton Antony , Jackson Michael , Millan Jose Luis

Medial vascular calcification (MVC) is a pathological condition common to a variety of diseases, including chronic kidney disease, diabetes, obesity, generalized arterial calcification of infancy, arterial calcification due to deficiency of CD73, and Keutel syndrome. These diseases share the common feature of tissue-nonspecific alkaline phosphatase (TNAP) upregulation in the vasculature. We developed a mouse model that overexpresses human TNAP in vascular smooth muscle cells, ...

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In vivo efficacy of a pharmacological inhibitor of TNAP to prevent arterial calcification and its associated cardiac hypertrophy and mortality

BiosciAbstracts