ba0004is21 | (1) (1) | ICCBH2015
Burnham Sandy
Pediatric inflammatory diseases are associated with low bone mass and fractures during childhood. In conditions such as inflammatory bowel disease and systemic lupus erythematosus, glucocorticoid therapy, and pro-inflammatory cytokines are key factors that impair bone accrual through specific effects on osteoblasts, osteoclasts, and osteocytes. Other factors may contribute to suboptimal skeletal maturation, including malnutrition, pubertal delay, low muscle mass, and physical ...