Bone Abstracts

Bone damage is one of the main unfavourable health effects of chronic exposure to cadmium (Cd). This heavy metal stimulates osteoclastic bone resorption and inhibits osteoblastic bone formation resulting in decreased bone mineralization and as a result weakening of the bone biomechanical properties. Recently, using a rat model of chronic human exposure to cadmium, we have revealed that even low exposure to this metal may increase bone vulnerability to fracture. Taking into acc...

Cadmium (Cd) is a toxic heavy metal characterized by strong cumulative properties in the human and animals’ organism. Although cadmium accumulation in the bone tissue is lower than in soft tissues such as liver and kidney, the bone-accumulated metal, even at low concentrations, can damage the bone tissue directly. Polyphenols are compounds possessing hydroxyl groups capable of binding divalent metals, including toxic metals, preventing their absorption from the gastrointe...

Cadmium is characterized by oxidative properties and this heavy metal-induced oxidative stress has been recognized to be involved in its injurious impact on the skeleton. Oxidative/reductive processes are an integral component of bone remodeling; however, destroying of the bone tissue oxidative/antioxidative status with excessive production and accumulation of reactive oxygen species has detrimental impact on bone metabolism. Thus, the aim of this study was to investigate whet...