Bone Abstracts

Existence of inflammatory osteoclasts (iOCLs) contributing to pathological bone resorption associated with inflammatory diseases has been suspected for many years. However, specific markers of iOCLs are lacking, making impossible to establish the contribution of iOCLs to such pathologies. Whereas in steady state OCLs derive from monocytes (MN-OCLs), in inflammatory conditions, they also differentiate from dendritic cells (DC-OCLs). We recently showed that these 2 OCL populatio...