ba0003lb2 | (1) | ECTS2014
Cummings Steven R
, Hue Trisha
, Cauley Jane A
, Bauer Doug C
, Ensrud Kristine E
, Barrett-Connor Elizabeth
, Black Dennis M
Purpose: To test whether bisphosphonates for osteoporosis reduce the risk of breast cancer.Background: Observational studies and meta-analyses find that women taking bisphosphonates have about a 1/3rd reduction in risk of breast cancer as soon as 1 year of treatment. This is plausible because bisphosphonates have in vitro anti-tumor activity and high doses of zoledronate reduce recurrence in women with breast cancer. However, observational studi...