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ba0005ws4.3 | Osteoporosis: Treat-to-target | ECTS2016

Uncoupling of resorption and formation; the tool to reach the treatment goal

Baron Roland

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ba0006is01 | (1) (1) | ICCBH2017

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Baron Roland

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ba0006is01biog | (1) (1) | ICCBH2017

Biographical DetailsDr Roland BaronDr Roland Baron is Professor of Medicine at the Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Professor in the Division of Bone and Mineral Research and Chair of the Department of Oral Medicine, Infection and Immunity at the Harvard School of Dental Medicine since January 2008. From 1977 -...

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ba0003OP5 | Clinical | ECTS2014

Continuous modelling-based bone formation could explain sustained increases in hip bone mineral density with denosumab treatment

Ominsky Michael S , Libanati Cesar , Boyce Rogely , Kostenuik Paul J , Baron Roland , Wagman Rachel B , Dempster David W

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ba0003pp355 | Osteoporosis: treatment | ECTS2014

Continuous modelling-based bone formation could explain sustained increases in hip bone mineral density with denosumab treatment

Ominsky Michael S , Libanati Cesar , Boyce Rogely , Kostenuik Paul J , Baron Roland , Wagman Rachel B , Dempster David W

In clinical studies, denosumab (DMAb) administration up to 8 years is associated with continued increases in bone mineral density (BMD) and low fracture incidence despite persistently low bone turnover markers and limited iliac crest tetracycline labelling (Papapoulos 2013). We tested the hypothesis that, with persistently low bone remodelling, BMD increases may result from a non-remodelling dependent mechanism to accrue bone matrix. We examined the fluorochrome labelling patt...

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ba0005oc2.1 | Bone mass and bone strength Wnt signalling | ECTS2016

Targeted deletion of Wnt1 in mesenchymal cells results in decreased bone mass and spontaneous fractures

Wang Fan , Tarkkonen Kati , Nieminen-Pihala Vappu , Rummukainen Petri , Lehto Jemina , Nagano Kenichi , Baron Roland , Makitie Outi , Kiviranta Riku

Wnt signaling is a major regulator of bone metabolism. We recently reported that mutations in WNT1 gene in humans cause early onset osteoporosis and severe osteogenesis imperfecta. To identify the cellular source and the mechanisms causing these severe phenotypes we generated and analyzed global and conditional Wnt1 knockout mice.Heterozygous Wnt1+/− mice were viable and fertile but Wnt1−/− embryos were lost in ute...

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Bone Abstracts

Limitations to anabolic stimulation of bone formation

Uncoupling of resorption and formation; the tool to reach the treatment goal

IS01

IS01

Continuous modelling-based bone formation could explain sustained increases in hip bone mineral density with denosumab treatment

Continuous modelling-based bone formation could explain sustained increases in hip bone mineral density with denosumab treatment

Targeted deletion of Wnt1 in mesenchymal cells results in decreased bone mass and spontaneous fractures

BiosciAbstracts