ba0005p108 | Cancer and bone: basic, translational and clinical | ECTS2016
Merlotti Daniela
, Rucci Nadia
, Rendina Domenico
, Bianciardi Simone
, Evangelista Isabella Anna
, Ucci Argia
, Rotatori Stefano
, Sebastiani Guido
, Dotta Francesco
, Cenci Simone
, Strazzullo Pasquale
, Nuti Ranuccio
, Teti Anna
, Gennari Luigi
Pagets disease of bone (PDB) is a common disorder of bone metabolism characterized by focal areas of excessive and rapid bone resorption and formation, leading to bone pain, deformity and fractures. Despite the well documented increase in the risk of primary bone tumors due to neoplastic degeneration of pagetic tissue, a large retrospective analysis suggested that patients with prostate cancer and PDB have delayed time to bone metastases and improved overall survival tha...