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ba0005p45 | Bone development/growth and fracture repair | ECTS2016

Mast cells regulate inflammation and bone regeneration in fracture healing

Kroner Jochen , Kovtun Anna , Messmann Joanna , Strauss Gudrun , Seitz Sebastian , Schinke Thorsten , Dudeck Anne , Ignatius Anita

Mast cells (MCs) are pro-inflammatory sensor and effector cells of the immune system. MCs seem to play a role in bone metabolism, because patients with systemic mastocytosis develop osteoporosis. MCs are present in the fracture callus during bone healing, however, their function has not yet been investigated. Here, we examined the role of MCs in the inflammatory and repair phase during fracture healing.Male 12-week old MC deficient mice (Mcpt5-Cre R-DTA)...

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ba0003OP27 | Pre-Clinical | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

see PP416....

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ba0003pp416 | Steroid hormones and receptors | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

Glucocorticoids (GCs) are widely used to treat chronic inflammatory diseases such as rheumatoid (RA) and lead to multiple side effects including glucocorticoid induced osteoporosis (GIO). Our work challenges the dogma that transrepression of pro-inflammatory genes by the glucocorticoid receptor (GR) is solely responsible for reducing inflammation, whereas transactivation of genes is causing side effects.Using conditional and function selective mutant mic...

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Bone Abstracts

Mast cells regulate inflammation and bone regeneration in fracture healing

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

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