Bone Abstracts

Purpose: Denosumab is a new potent antiresorptive treatment of osteoporosis that can potentially induce a compensatory increase of parathyroid hormone (PTH) levels. We aimed to evaluate the alteration of PTH 1 and 6 months after denosumab’s administration (60 mg) with different regimens of calcium and vitamin D (Ca/D) supplementation, as well as the association of PTH with serum Ca and bone markers.Methods: This was a prospective, multicenter, study...

Circulating microRNAs (miRNAs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. The aim of the present study was to investigate the differential expression of specific circulating micro RNAs known to regulate bone metabolism and homeostasis in postmenopausal osteoporotic women with and without vertebral fractures. For the analysis, miRNAs were isolated from the serum of 24 osteoporotic patients with at least one moderate vertebr...

Circulating microRNAs (miRNAs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. The aim of the present study was to investigate the differential expression of specific circulating micro RNAs known to regulate bone metabolism and homeostasis in postmenopausal osteoporotic women with and without vertebral fractures. For the analysis, miRNAs were isolated from the serum of 24 osteoporotic patients with at least one moderate vertebr...