Bone Abstracts

Objectives: This study aimed to evaluate detailed bone profiles during puberty for Chinese adolescents in Hong Kong using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy x-ray absorptiometry (DXA).Methods: 333 healthy girls and 231 healthy boys (12–16-years-old) were recruited from secondary schools. Areal bone mineral density (aBMD) of bilateral femoral necks were measured by DXA while bone quality parameters w...

Several environmental and genetic factors are determinant, also including sex, hormonal, ethnics, nutritional and lifestyle, may interferer on bone mass of children. However, the pediatric studies that approach the socioeconomic status and the quantitative ultrasound parameters (QUS) are scarce. The aim of this study was to compare the socioeconomic status on bone mass assessed by QUS in boys from 7 to 15 years old. In this cross-sectional study, were evaluated 520 Brazilian b...

Introduction: Presence of osteosynthetic material in the spinal region may result in decreased musculoskeletal activity in certain spinal column segments, leading to vertebral bone mineral density changes.Case study: The case involves a 12-year-old girl who was born prematurely, who complained of experiencing lower back pain after performing forward roll in the physical education class. The patient was born at 32 weeks of gestation by pelvic presentation...

Osteoclasts are cells specialized for resorption of calcified tissue. Osteoclasts are formed from precursor cells of monocyte lineage under the control of receptor activator of nuclear factor kappaB ligand (RANKL). Mitogen- and stress-activated protein kinase 1 (MSK1) has been reported to be an important regulator of immune response and mitogenic signaling. In this study, we for the first time found that MSK1 was activated by RANKL in osteoclast precursor, bone marrow macropha...

Objective: It was proved that expansive pedicle screw (EPS) could significantly enhance immediate screw stability through mechanical expanding and compressing. However, there were little researches on growth of bone tissue around screw and dynamic screw stability in vivo in osteoporotic vertebrae. This study was designed to evaluate growth and microstructure of bone tissue around screw and fixation strength of screw in osteoporotic sheep lumbar vertebrae.<p class=...

Indoxyl sulfate (IS) is one of a number of protein-bound uremic toxins that accumulate in patients with chronic kidney disease. Current conventional hemodialysis is ineffective at removing this toxin. Although IS may impair osteoblast function and induce abnormalities of bone turnover or arthropathy, the effects on knee joint tissue by IS has not been investigated yet. The present studies have been carried out to test the IS effects on synovial fibroblasts, meniscal fibrochond...

Objectives: Osteonecrosis (ON) and decline of bone mineral density (BMD) are serious side effects during and after treatment of childhood acute lymphoblastic leukemia (ALL). It is unknown whether ON and low BMD co-occur in the same patients, and whether these two osteogenic side-effects can mutually influence each other’s development.Methods: BMD and the incidence of symptomatic ON were prospectively assessed in a national cohort of 466 patients wit...

Background: Familial hypocalciuric hypercalcemia (FHH) is a rare autosomal dominant condition with an estimated prevalence of 1 in 78,000. The commonest cause of FHH is inactivating mutations of the calcium-sensing receptor (CASR) gene, with the rest mostly caused by missense mutations of the GNA11 and AP2S1 genes. FHH is characterized by persistent mild-to-moderate hypercalcemia, hypocalciuria with calcium-creatinine clearance ratio ⩽0.01. The disease runs a benign cou...

Background: Asian-specific prediction model for estimating the individual risk of osteoporotic fracture was rare. We aimed to develop a Korean fracture risk prediction model using clinical risk factors and assess external validity of the final model.Methods: A total of 718,306 Korean men and women aged 50–90 were followed for 7 years in national system based cohort study. Fifty percent were randomly assigned to the development dataset and 50% to the...

Objective: Chondrolysis, chondrocyte apoptosis, and local inflammation are described to exacerbate osteoarthritis development. We therefore aimed to investigate the effect of adrenomedullin (ADM) and its truncated peptide (22–52ADM) on in vitro and in vivo models. Both have exhibited anti-apoptotic and anti-inflammatory properties in collagen-induced arthritis (CIA) in mice.Methods: In normoxia or hypoxia (physiological condition),...