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Introduction: Fracture healing is impaired in aged and osteoporotic patients. Because bone formation is tightly regulated by the mechanical conditions in the fracture gap and because suitable mechanical stimuli improve fracture healing (Claes et al. 1998), we investigated whether low-magnitude high-frequency vibration (LMHFV; Rubin et al. 2004) is able to improve delayed fracture healing induced by age and ovariectomy in mice.Sudy desig...

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ba0001oc2.4 | Bone quality and fracture repair - animal models | ECTS2013

PPARβ deficiency induces muscle and bone loss with aging but does not impair the bone biomechanical response to loading: a sarco-osteopenic mouse model

Bonnet Nicolas , Desvergne Beatrice , Ferrari Serge

Pparβ is crucial for muscle fatty acid oxidation. Pparβ−/− mice have reduced muscle strength, exercise performance, and also a decreased skeletal response to exercise. Here we investigate the influence of Pparβ on muscle and bone loss with aging, and its role on the bone biomechanical response to loading. Pparβ−/− and Pparβ+/+ mice were monitored at 1, 3 and 18...

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ba0001oc2.5 | Bone quality and fracture repair - animal models | ECTS2013

Glucagon-like peptide 1 receptor is required for optimal bone strength and quality

Mieczkowska Aleksandra , Irwin Nigel , Flatt Peter R , Chappard Daniel , Mabilleau Guillaume

Objectives: Glucagon-like peptide 1 is secreted by intestinal L-cells into the blood supply in response to nutrients in the intestine. Although osteoblasts express the GLP-1 receptor (GLP-1R), the main action of the GLP-1/GLP-1R pathway in bone physiology and bone quality is unknown. The aim of the present study was to investigate bone strength and quality in a mouse model of GLP-1R deficiency.Materials/methods: Eight 16 weeks-old GLP-1R knock-out male m...

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ba0001oc2.6 | Bone quality and fracture repair - animal models | ECTS2013

GH excess in bGH transgenic mice adversely affects bone density, architecture and quality

Lim Su-Vern , Marenzana Massimo , List Edward , Kopchick John , Korbonits Marta , Chenu Chantal

GH is an important anabolic hormone involved in the regulation of longitudinal bone growth. However, acromegaly patients have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice to analyse the effects of high serum GH levels on BMD, architecture and mechanical strength. Five month-old hemizygous male bGH mi...

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ba0001oc3.1 | Osteoporosis pathophysiology and genetics | ECTS2013

Heavy cannabis use negatively impacts on bone density: a population based prospective study

Sophocleous Antonia , McKenzie James , Robertson Roy , Ralston Stuart H

The endocannabinoid system has important effects on bone mass and bone turnover. Mice with targeted inactivation of type 1 (CB1) and type 2 (CB2) cannabinoid receptors develop osteoporosis with increasing age raising the possibility that cannabinoid receptor agonists might protect against age-related bone loss. Since cannabis is the most widely used illegal drug and its main psychotropic component -Δ9-tetrahydrocannabinol (THC)- is an agonist at CB1 and CB2 receptors, we ...

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ba0001oc3.2 | Osteoporosis pathophysiology and genetics | ECTS2013

Abstract withdrawn....

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ba0001oc3.3 | Osteoporosis pathophysiology and genetics | ECTS2013

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross sectional study of young adult males and females

Deere Kevin , Sayers Adrian , Viljakainen Heli , Lawlor Debbie , Sattar Naveed , Kemp John , Fraser William , Tobias Jon

Introduction: Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development.Design: We aimed to compare associations between intramuscular and subcutaneous fat and cortical bone outcomes in young adults, in cross-sectional analyses based on the Avon Longitudinal Study of Parents and Children.Method: Data were collected from a research clinic conducted at 17 years of age. Intramuscula...

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ba0001oc3.4 | Osteoporosis pathophysiology and genetics | ECTS2013

Cortical exceeds trabecular bone loss before menopause but net bone loss is modest because periosteal apposition occurs

Bjornerem Ashild , Wang Xiaofang , Ghasem-Zadeh Ali , Bui Minh , Hopper John , Zebaze Roger , Seeman Ego

Introduction: Bone mineral density decreases before menopause and is held to be due to trabecular, not cortical, bone loss. Yet neither a negative bone balance, nor accelerated remodelling occurs before 45 years of age. We hypothesized that bone loss will first appear after 45 years and will be cortical (as 80% of bone is cortical).Methods/design: Images of distal tibia acquired using high-resolution peripheral quantitative computed tomography (Scanco Me...

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ba0001oc3.5 | Osteoporosis pathophysiology and genetics | ECTS2013

Genome-wide association identifies a new susceptibility locus at 4q35 associated with clinical vertebral fractures in post-menopausal women: the GEFOS-GENOMOS consortium

Alonso N , Estrada K , Herrera L , Kabir D , Olmos J M , Sanudo C , Riancho J A , Oei L , Medina-Gomez M C , Stenkjaer L , Bjerre L , Langdahl B , Brown M A , Duncan E L , Sims M , Kaptoge S , Reeve J , Lewis J , Prince R , Reppe S , Olstad O K , Gautvik K M , Garcia-Giralt N , Nogues X , Mencej-Bedrac S , Marc J , del Pino J , Gonzalez-Sarmiento R , Wolstein O , Eisman J , Feenstra B , Melbye M , Albagha O M E , WTCCC , Davies G , Starr J , Deary I , Quintela I , Fernandez C , Carracedo A , Lucas G , Elosua R , Uitterlinden A G , Rivadeneira F , Ralston S H

Vertebral fractures (VF) defined by morphometric analysis of spine radiographs are the most common complication of osteoporosis. Those that come to medical attention, with symptoms such as back pain and kyphosis are termed clinical vertebral fractures (CVF) and account for significant morbidity and mortality. Although much progress was made in identifying loci for bone mineral density, the genetic determinants of CVF remain unclear. Here we present the initial results from a g...

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ba0001oc3.6 | Osteoporosis pathophysiology and genetics | ECTS2013

Causal metabolomic pathways to osteoporosis in elderly women

Moayyeri Alireza , Hart Deborah , Erte Idil , Mangino Massimo , Hammond Christopher , Spector Timothy

Background: Recent technological omics advances have empowered us to identify associations between genetic markers and various traits. Knowledge of serum metabolites as intermediary phenotypes can help us achieve a better understanding of the causal pathways from genes to complex diseases like osteoporosis.Methods: In the context of TwinsUK study, serum metabolomic profiles of 6055 participants were assessed using a non-targeted mass spectrom...

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Bone Abstracts

Low-magnitude high-frequency vibration improves fracture healing in aged, ovariectomized mice

PPARβ deficiency induces muscle and bone loss with aging but does not impair the bone biomechanical response to loading: a sarco-osteopenic mouse model

Glucagon-like peptide 1 receptor is required for optimal bone strength and quality

GH excess in bGH transgenic mice adversely affects bone density, architecture and quality

Heavy cannabis use negatively impacts on bone density: a population based prospective study

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross sectional study of young adult males and females

Cortical exceeds trabecular bone loss before menopause but net bone loss is modest because periosteal apposition occurs

Genome-wide association identifies a new susceptibility locus at 4q35 associated with clinical vertebral fractures in post-menopausal women: the GEFOS-GENOMOS consortium

Causal metabolomic pathways to osteoporosis in elderly women

BiosciAbstracts