Bone Abstracts

RANKL is the central player in the regulation of osteoclastogenesis and the quantity of RANKL presented to osteoclast precursors is an important factor determining the magnitude of osteoclast formation. It had been believed for years that osteoblastic cells are the major source of RANKL presented to osteoclast precursors, and we have previously focused on RANKL intracellular behavior in osteoblastic cells. However, recent two reports controverted this traditional concept and s...

Objectives: Osteogenesis Imperfecta (OI) is a heritable brittle bone disease mainly caused by mutation of COL1A1 or COL1A2. Treatment with bisphosphonate is not effective enough in patients with severe OI. 4-phenylbutyric acid (4-PBA) may become a new medicine, which was reported to ameliorate the phenotype of an OI zebrafish model. In the present study, we aimed to analyze the pathology of OI and the effects of 4-PBA on patient-derived fibroblasts and induced pluripotent stem...

Objective: Little is known about the effects of muscle strength and muscle mass on bone health in children and adolescents. We examined the relative impact of muscle strength and muscle mass on bone mineral density in Japanese adolescents.Methods: Subjects were 236 adolescents aged 15–18 years in August 2010 and August 2013 who were enrolled in the Kitakata Kids Health Study in Japan. Cross-sectional data including appendicular skeletal muscle mass ...

Objective: To investigate the effect of growth hormone (GH) treatment on glucose metabolism in achondroplasia (ACH) patients.Patients and methods: Twenty-five GH-treated (0.35 mg/kg/week) ACH patients (10 males and 15 females) were included in this study. Oral glucose tolerance test (OGTT) was performed at three time points; ‘pre-treatment’ (age: 4.0±1.9 years), ‘post short-term treatment’ (age: 6.5±3.0 years), and ‘pos...