Bone Abstracts

Objectives: Vertebral fracture (VF) is a hallmark of osteoporosis, and it increases morbidity, mortality and large amount of medical cost. In this study, we aimed to describe the treatment pattern and estimate the cost of VF among elderly patients in Korea.Methods: Using Korean national healthcare claims database, we analyzed a 2% sample of patients aged ≧ 50 years between years of 2008 and 2012. New VF was identified on the basis of selected ICD-10 c...

Objective: Bone is one of endocrine organ and osteocytes secretes FGF23, Sclerostin and DKK1. FGF23 inhibits renal phosphate reabsorption and suppresses 1-α hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of single bolus injection of vitamin D on serum FGF23, DKK1 and Sclerostin concentrations in vitamin D-deficient subjects.Design and methods: The study group was composed of placebo group with s...

Discordance of T-score is frequently observed and affects to therapeutic strategy in osteoporosis. Z-score discordance in premenopausal women has not been reported yet. In addition, despite of important role of low bone mineral density (BMD) in premenopausal women to predict osteoporotic fracture in postmenopausal age, there are very few reports on the status of low BMD in healthy premenopausal women. To investigate the current status of idiopathic osteoporos...

Mutations in PLEKHM1 cause bone disease in humans and animals. Truncations causedeficient bone resorption by osteoclasts leading to osteopetrosis. A gain-of-function point mutation causes increased resorption leading to osteopenia. We and others have shown that PLEKHM1, a multi-modular protein, interacts with the small GTPase rab7 and is involved in vesicle trafficking, secretion, and membrane biogenesis. To investigate other interactions of PLEKHM1 we performed tandem affinit...

Background and objectives: The association between excess calcium intake and cardiovascular mortality has been reported, but the association has not yet been explored according to serum vitamin D status. Thus, we investigated the relation of dietary calcium intake and Framingham risk score (FRS) according to serum 25-hydroxyvitamin D (25(OH)D) status.Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years from the data of the Ko...

Estradiol (E2) signaling via estrogen receptor alpha (ERα) is important for the male skeleton as demonstrated by ERα inactivation in both mice and man. ERα mediates estrogenic effects by translocating to the nucleus and there affects gene transcription, but some effects can also be mediated via extra-nuclear actions of the receptor by, e.g., triggering cytoplasmic signaling cascades. ERα contains various domains and the role of activation functio...

Background: Many studies have demonstrated that waist-to-height ratio (WHtR) correlates with risk factors of coronary artery disease (CAD) better, than the body mass index (BMI). Coronary artery calcification (CAC) is an independent risk factor of atherosclerotic heart disease. However, the association between WHtR and coronary artery calcification scores (CACS) still need to be elucidated. The purpose of this study was to investigate the relationship between WHtR and CACS in ...

Objectives: To evaluate risk factors of subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.Methods: As a multicenter retrospective study, we recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at 1-year follow-up in three hospitals. The patients were divided into two groups according to occurrence of subsequent vertebral fracture. Two groups were analyzed with ...

Background and objectives: Fracture in rheumatoid arthritis (RA) patient is more frequent than general population. One of the important reasons is use of glucocorticoid (GC) for treatment of RA. In this study, we aimed to identify the effect of GC on fracture of different site.Methods: Among RA patients ≧19 years, we established a retrospective cohort using Korean national healthcare claims database from Jan 2010 to Dec 2010, and then followed up unti...

Background: The prevalent vertebral fracture (VF) is a risk factor for future VF, which can be decreased with drug therapy. However, most VFs are not recognized clinically. VFA by DXA and spine X-ray can be performed to detect these prevalent VFs.Objectives: This study aimed to estimate the costs, effectiveness, and radiation exposure of VF diagnostic strategies.Methods: Markov model over a 10-year period was used to calculate the ...