Bone Abstracts

Objective: The study of melatonin on the levels of autophagy in bone will contribute to new type 2 diabetes osteoporosis-pathological processes by which a specific role and mechanism for the treatment of type 2 diabetes-induced osteoporosis could emerge.Method: This study consists of a two-part experiment. We assessed different body parameters in rats, a type 2 diabetes model application, utilizing different concentrations of melatonin interventions, the...

Objective: To analyse the influential factors of lifestyle on vitamin D status among aged people in Shanghai community.Method: Lifestyles of 3846 elderly men and women aged over 65 years were investigated using a self-designed questionnaire from ten communities of urban and suburb in Shanghai China, which contained sociodemographic factors and lifestyle factors and so on. The levels of serum 25(OH)D were measured by Cobas Diagnosis System of Roche. Univa...

When cells detach from or re-attach to the substrates, there is a drastic change in shape. Molecular mechanism by which controls shape upon cell attachment to the substrates was studied in osteoblastic MC3T3-E1 cells in vitro. Most striking feature found in the ovoid cells detached from the substrates was densely packed cortical actin bundles (CAB) encircling cells. Cells lost the CAB upon attachment and spreading on to the substrates. CABs were under control of small...

Toll-like receptors (TLRs) appear to be involved in the pathogenesis of osteoarthritis (OA) and recent studies have suggested that polymorphisms in TLR9, an endosomal TLR are associated with knee OA in at least one population. TLR3 is also found on the surface of endosomes where they respond primarily to nucleic acid based pathogen-associated molecular patterns (PAMPs) from viruses and bacteria. We therefore determined the predictive value of TLR3 gene polymorphisms and furthe...

Objectives: Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. Receptor activator of NF-κB ligand (RANKL) induces Ca2+ oscillations and activates nuclear factor of activated T cells 1 (NFATc1) during osteoclast differentiation. Although Ca2+ oscillations play a key role for o...

Objectives: Sex hormones and mechanical overload have been regarded as main causative factors in the pathogenesis of temporomandibular joint (TMJ) osteoarthritis. However, there was no report regarding the relevance of mechanical overload on the mandibular condyle with serum estrogen level. This study aimed to investigate changes of the mandibular condyle of TMJ in ovariectomized rat under increased loading, and to evaluate the inhibitory effect of systemic administration of 1...

Leptin and adiponectin have an opposing relationship in circulation; leptin is higher and adiponectin lower in overweight/obese individuals, and vice versa. Studies showed that both leptin and adiponectin can be either beneficial or harmful to bone depending on the mode of action. The objective was to investigate the association of serum leptin:adiponectin ratio (L:A) with BMD of various skeletal sites and markers of bone turnover in overweight and obese postmenopausa...

The connection between osteoporosis and obesity is becoming a topic of increasing research. The adipocyte-secreted hormones, leptin and adiponectin, may be the mediators between adipose tissue and bone. The aim was to examine the changes in leptin and adiponectin with the weight and body composition (fat and lean mass) change during the 6-months weight loss program. Additionally, the relationship between two adipokines and BMD of various skeletal sites was also examined. Parti...

Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. RANKL (receptor activator of NF-kB ligand) induces Ca2+ oscillations and activates NFATc1 (nuclear factor of activated T cells i) during osteoclast differentiation. Although Ca2+ oscillations play a key role for osteoclastogenesis...

Introduction: Low level of estrogen has regarded as a main contributing factor of temporomandibular joint (TMJ) arthritis in young women patients. However, there is lack of evidence about the occurrence of arthritis in knee joint (KJ) related with estrogen deficiency. This study aimed to investigate the effect of estrogen deficiency on the loaded and non-loaded bone area of TMJ or KJ.Method and materials: Total of 28 SD rats were allocated into two group...