Bone Abstracts

Purpose: PK-VF study, being conducted in 2007–2008 and 2012–2013, was aimed to investigate the prevalence and 5-year incidence of vertebral fractures (VFs) in postmenopausal women aged 50 years or older in Beijing, China.Methods: In the 2007–2008 survey, we randomly selected a community-based population of 1825 postmenopausal women, of whom 952 women also participated in the 2012–2013 survey. Adopting the same sampling strategies as 2...

Purpose: The aim of this 5-year prospective study was to investigate the association between type 2 diabetes mellitus (T2DM) and incident osteoporotic fracture (IOF) in Chinese postmenopausal women aged 50 years or older.Methods: We included 826 subjects, participating in both the baseline (2007–2008) and follow-up (2012–2013) studies. Based on the diagnosis of T2DM, subjects were first individualized into Non-T2DM and T2DM groups, which were t...

Odanacatib (ODN), a selective and reversible cathepsin K inhibitor was shown to histomorphometrically reduce trabecular (Tb) and intracortical (Ic) bone remodeling while preserving endocortical (Ec) and stimulating periosteal (Ps) bone formation (BF) in monkeys. Here, we investigate the bone site specific mechanism of ODN on bone modeling (Mo) versus remodeling (Re)-based osteons. Rhesus monkeys (13–19 yrs, n=8–11/group) were ovariectomized and treated with ...

Objectives: To evaluate the clinical outcomes of intravenous bisphosphonate treatment in children with mild-moderate osteogenesis imperfecta (OI) who had progressed from active bisphosphonate treatment to maintenance therapy for >2 years.Methods: A retrospective review was conducted on 17 patients with mild-moderate OI. Clinical data, fracture history, biochemistry, dual energy X-ray absorptiometry (DXA) parameters, vertebral measurements, bone age a...

The high prevalence of renal osteodystrophy (ROD) in pediatric renal transplant recipients has been linked to the duration on dialysis pre transplant, exposure to steroids, nutritional deficiencies, limitations in physical activity and ethnicity. The incomplete resolution of ROD in transplant recipients has been found to be associated persistent abnormalities in mineral metabolism associated with allograft dysfunction in the post transplant period.We hyp...

Objective: To analyse the influential factors of lifestyle on vitamin D status among aged people in Shanghai community.Method: Lifestyles of 3846 elderly men and women aged over 65 years were investigated using a self-designed questionnaire from ten communities of urban and suburb in Shanghai China, which contained sociodemographic factors and lifestyle factors and so on. The levels of serum 25(OH)D were measured by Cobas Diagnosis System of Roche. Univa...

Objective: To test the hypothesis that the cemented and uncemented implants had effect on the measurement of proximal femur BMD by DEXA.Methods: 40 patients underwent unilateral THA using cemented (n=20) and uncemented (n=20) implants due to developmental dysplasia of the hip, femoral neck fracture or femoral head necrosis from January 2015 to July 2015 were included. Preoperative DEXA scans were acquired for the BMD of the posteroanter...

Background: Women with breast cancer (BC) are at high risk for fracture due to the deleterious impact of BC therapies on bone. In China, BC survival is improving as screening and treatment programs expand, however no guidelines exist to prevent BC treatment-induced bone loss. We sought to evaluate the scope of this problem among BC survivors receiving care at a large cancer referral hospital in China.Methods: Women were invited to participate in this cro...