Bone Abstracts

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Purpose: Multipotent stromal cells (MSC) have been considered promising for the regenerative strategies of articular cartilage. However, the MSC chondrogenic differentiation can ultimately lead to the formation of hypertrophic chondrocytes responsible for the calcification of cartilage. To prevent this MSC-dependent production of a calcified matrix in articular site, MSC hypertrophic differentiation has to be carefully controlled. Given that articular cartilage is avascular, w...

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Subchondral bone remodelling and osteophyte growth are widely recognised hallmarks of knee osteoarthritis (OA) although their contribution to disease is not fully understood. Murine models, with targeted genetic modifications, have become powerful tools for discovering disease pathophysiology. Our unpublished observations suggest that osteophyte formation is independent of cartilage loss thereby implying potentially independent molecular drivers. We have developed a novel imag...

Biographical DetailsDr A Linglart is a Paediatric Endocrinologist working at the Hôpital St Vincent de Paul in Parism, France. She has a special interest in rare diseases....

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Study aim: Vertebral strength is determined by bone size, shape, bone mineral density, microarchitecture, and bone material properties. Despite its importance to vertebral mechanics, no studies have reported on the variation of bone microdamage present in the human vertebra. Thus, the aim of this study was to assess regional changes in trabecular bone microdamage in association with bone microarchitecture and resorption in whole human lumbar vertebrae.Me...

Study aim: The general assumption that changes in bone microstructure and material properties at the iliac crest are representative of skeletal sites that are susceptible to osteoporotic fracture has not yet been addressed. Therefore, our study aim was to perform a comparative analysis of bone microarchitecture, accumulated microdamage and osteocyte morphology between the iliac crest, proximal femur and vertebral body.Methods: Trabecular bone cores were ...

Aim: Differences in fracture risk between ethnic groups have been documented. The basis for these differences is yet incomplete and the age at what ethnic differences appear is uncertain. Assessment of bone health in pediatric populations could bring insights on factors compromising bone accrual. We describe here differences in total body bone mineral density (TB-BMD) in a unique setting of children of the same age, measured with the same device (iDXA) different ethnic backgro...

Bisphosphonates (BPs) such as zoledronic acid (ZA) are widely used to treat bone diseases. The use of BPs can lead to osteonecrosis of the jaw (ONJ), but it is not clear why in particular the jaw bone is affected. Previously, it was shown that osteoclasts derived from different bone sites have different properties. We hypothesize that BPs have distinct effects on bone-site specific osteoclasts or precursors. To investigate this, female C57BL/6J mice were injected intraperitone...