Bone Abstracts

Introduction: The recent studies show high prevalence of vitamin D deficiency and insufficiency all over the world. Vitamin D deficiency can cause serious problems such as rickets in children and osteomalacia in adults.The aim of the study was to determine the influence of vitamin D deficiency on bone mineral density.Methods: There were examined 304 children aged 10–18 years. The boys consisted 53%. The average age of boys was...

Introduction: Vitamin D is an essential material in bone metabolism, and regulation of body minerals. Vitamin D deficiency has various causes, including limitations in sunlight exposure (type of clothing, sunscreen usage, indoor activity), seasonal geographic latitude and altitude, atmospheric pollution, diet, and ageing.The aim of the work was to determine the frequency of vitamin D deficiency among Ukrainian schoolchildren and its influence on bone min...

The aim of the work was to determine the influence of vitamin D deficiency on bone mineral density in schoolchildren.Methods: There were examined 304 children aged 10–18 years. The boys consisted 55.0%. The average age of boys was 12.9±0.2 and girls – 12.4±0.2 years old. Researches included ultrasound densitometry of calcaneus by SAHARA (Hologic), blood chemistry, 25(OH)D and intact parathyroid hormone (iPTH) in plasma were determined...

Aim: To determine the response to treatment, clinical and instrumental features in children with partial GH deficiency (pGHD) and severe GHD (sGHD).Methods: We examined retrospectively 30 children with isolated GHD (stage on Tanner 1) in the Endocrinological department of University hospital (Minsk) over 2004–2012 years. Group 1 (G1) – children with pGHD (n=5) mean±S.D., age 6.3±1.4 years; group 2 (G2) – s...

Subject: To examine the relationship between calcification of the coronary arteries, coronary atherosclerosis and indicators of bone mineral density (BMD) among males with coronary heart disease (CHD).Materials and methods: Seventy-four males with documented CHD were examined. BMD was assessed by dual energy absorptiometry with T-criterion definition of the proximal femur and lumbar spine, coronarography, multispiral computed tomography with quantificati...

Deceased donor kidneys are exposed to cold ischemic insult, which makes them particularly susceptible to the effects of cold ischemic injury during hypothermic preservation resulting in high rates of delayed graft function. Although cold storage reduces cellular oxygen demand, ischemia causes the rapid depletion of adenosine triphosphate and accumulation of toxic substances leading to cell death. BMP-7 is a valuable reagent in a field of tissue regeneration and preservation un...

Background: Optimal intake of calcium and vitamin D of pregnant women is an important component for the normal course of pregnancy, but here are the contradictory opinions about the case of shortage of the consumption, there is no uniform approach to the appointment of them.Aim: To assess the level of consumption of alimentary calcium, and characteristic of the status of vitamin D and calcium in blood serum of pregnant women.Materi...

Objectives: The aim is to examine the serum levels of 25(OH)vitamin D in children and adolescents with type 1 diabetes mellitus and in healthy controls and to determine whether patients with diabetes have higher prevalence of vitamin D deficiency/insufficiency and whether it is correlated to its metabolic control.Methods: A cross-sectional study of 73 patients (35 males) aged 11.84±4.44 years and 27 healthy controls (15 males), aged 7.36±4.71 y...

The problem of early diagnosis of rheumatoid arthritis remains an important area of research in rheumatology. We investigated changes in bone metabolism, bone mineral density in early rheumatoid arthritis (ERA; up to 12 months). Data were compared with changes in the MRI study of the dominant hand.We observed 24 patients with ERA, the average age – 33.6±5.7 years. The men were 6 (25%), women – 18 (75%). Bone mineral density (BMD) was deter...

Bone resorption and deposition occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance between bone synthesis and resorption, including osteoporosis and skeletal metastases. The uncoupling of remodeling activities contributes to disseminated tumor cells homing to the bone and to tumor growth in bone. Therefore, a reliable marker of bone remodeling would be useful to provide a st...