Bone Abstracts

Introduction: Minodronate, a new-generation bisphosphonate (BP), is the first BP available as a once-monthly oral regimen in Japan. Aside from being a highly potent inhibitor of bone resorption, minodronate has been shown to possess antagonistic action against the P2X2/3 receptor, which has an important role in nociceptive transmission. The purpose of this study was to investigate the analgesic effects of once-monthly oral minodronate (MIN50 mg) on low back pain (LBP) associat...

Introduction: Minodronate, a highly potent, new-generation bisphosphonate (BP), is the first BP available as a once-monthly oral regimen in Japan. The aim of the present study was to investigate the effects of once-monthly oral minodronate on bone turnover markers (BTM) and bone mineral density (BMD) in osteoporotic patients previously using daily or weekly BPs in real clinical practice.Methods: We conducted a prospective multicenter study involving 11 i...

Introduction: Bisphosphonates (BPs) are currently the mainstay of treatment in osteoporosis; however, the complex dosing regimens might interfere with long-term adherence, which provided the rationale to develop BPs with less-frequent dosing schedules. Minodronate (MIN 50 mg), a highly potent new-generation BP, is the first BP available as a once-monthly oral regimen in Japan. The aim of the present study was to investigate patient preference for, and adherence to, MIN 50 mg i...

ACH (achondroplasia) is one of the most common skeletal dysplasias with severe short stature caused by gain-of-function mutations in the FGFR3 gene. Foramen magnum stenosis is a serious neurological complication of ACH. Downregulation of the FGFR3 signaling is a radical therapeutic strategy for the disease. We previously demonstrated that meclozine, an over-the-counter drug for motion sickness, inhibited elevated FGFR3 signaling in chondrocytic cell lines. In the present study...

Objectives: We have performed a novel cell therapy using culture-expanded bone marrow cells (BMC) and platelet rich plasma (PRP) during limb lengthening procedure since 2002. In the present study, we evaluated the efficacy of the cell therapy on new bone regenerates in patients with achondroplasia (ACH) and hypochondroplasia (HCH).Methods: The transplantation technique of BMC and PRP was described previously (Bone 40: 522–528, 2007). Inclusion crite...

RANKL is the central player in the regulation of osteoclastogenesis and the quantity of RANKL presented to osteoclast precursors is an important factor determining the magnitude of osteoclast formation. It had been believed for years that osteoblastic cells are the major source of RANKL presented to osteoclast precursors, and we have previously focused on RANKL intracellular behavior in osteoblastic cells. However, recent two reports controverted this traditional concept and s...

To assess the associations among diseases causing disability requiring support, including i) musculoskeletal diseases (knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP)); ii) metabolic risk factors for cardiovascular diseases, including overweight (OW), hypertension (HT), dyslipidaemia (DL), and impaired glucose tolerance (IGT); and iii) mild cognitive impairment (MCI).Among 1690 participants (596 men and 1094 women) at the baseli...

We previously reported that interleukin (IL)-11 plays an important role in the mechanical stress and PTH-induced stimulation of osteoblast differentiation and bone formation. Mechanical stress and PTH enhance IL-11 gene promoter activity and increase IL-11 expression. Increased IL-11 down-regulates dikkopf 1/2 (Dkk1/2) expression and stimulates canonical Wnt signaling, which enhances osteoblast differentiation. The present study was undertaken to clarify the physiological role...

Objectives: Chronic non-bacterial osteomyelitis (CNO) is a heterogenic group of immune-mediated inflammatory bone diseases with unclear pathogenesis. Only a few genes associated with this condition have identified. The aim of the study was to evaluate the spectrum of mutations in genes associated with primary immunodeficiency syndromes (PIDs) and autoinflammatory diseases (AIDs) in the cohort of patients with early-onset CNO from North Caucasus (Dagestan and Chechnya) and asse...

The aim of this study was to investigate the biocompatibility of hydroxyapatite (HAP) powder from whitemouth croaker fish (Micropogonias furnieri). For this purpose, fragments from HAP with 0.5 cm2 were inserted in the subcutaneous tissue of animals. After 7, 15, and 30 days, histopathological analysis was performed. The results showed that it was possible to detect tissue reactions closely related to cytotoxicity in a time-exposure manner. At day 7, modera...