Bone Abstracts

Background: It is inadequate to use the patient’s age and sex alone to estimate physicians’ workload in the primary setting. The extent to which the morbidity burden of osteoporosis patients would account of the utilization of primary care services has not been examined.Aim: We analyzed the number of face-to-face visits of osteoporosis patients visiting Danish GP clinics and aimed to assess what proportion of primary care services variation are...

Differentiation of osteoclast progenitor cells into mononucleated TRAcP+ pre-osteoclasts occurs in the bone marrow. But how are these cells dispatched to the future bone resorption sites? We hypothesized that the collagen type III/I-rich reticulin network of the bone marrow might provide a structural framework for localization and migration of differentiating pre-osteoclasts towards the bone surface. Therefore, adjacent sections from decalcified paraffin-embedded iliac crest b...

It is still unknown where from osteoblasts are recruited during remodeling of adult human cancellous bone. Still, it is often suggested that they originate from perivascular osteoprogenitors in the bone marrow (BM). Here we propose also the existence of a layer of osteoprogenitors at the periphery of the BM. This proposal is based on electron and light microscopy of the bone surface and of the neighboring BM in human iliac crest biopsies, where we quantified cell densities, ce...

Aim: To determine the safety, tolerability, pharmacokinetics and pharmacodynamics of the cathepsin K inhibitor MIV-711.Methods: A double-blind, placebo-controlled, randomized study in 27 healthy subjects of both genders. Single ascending doses 20–600 mg were investigated for adverse events, clinical chemistry, vital signs, ECG parameters, pharmacokinetics, and serum levels of CTX-I.Results: MIV-711 was well tolerated with no a...