Bone Abstracts

Neurofibromatosis type I (NF1) is a monogenetic disorder caused by mutations in the NF1 gene encoding for the Ras-GAP protein neurofibromin. Apart from benign tumour development NF1 is frequently associated with skeletal manifestations such as osteopenia or debilitating focal skeletal dysplasia. To assess a function of Nf1 in osteocytes we here apply a combinatorial approach of biophysical, histological and molecular techniques allowing differential analysis ...

The term ‘inflammatory bowel disease’ (IBD) describes a chronic and relapsing inflammation. Up to 25% of all patients with IBD develop the disease during childhood and adolescence. IBD is considered one of the most common chronic childhood diseases in the Western world. Besides epidemiologic data, a short overview about disease presentation, diagnostic criteria and current treatment strategies will be given.The etiology of IBD is still unknown ...

Biographical DetailsS Schmidt graduated with a medical degree from the University of Rostock (Germany) in 1996 and received her pediatric training in Germany, Norway and Sweden. Already during this time she became interested in pediatric inflammatory bowel disease and bone mineral density. After residency, she worked as a pediatric gastroenterologist in the region of Gothenburg (Sweden) a...

Numerous studies in adult patients with type 1 diabetes (T1D) described an association with reduced bone mineral density, altered bone geometry and osteoporosis. Epidemiologic data on hip fractures demonstrate an increased risk in a large adult population with T1D. Diabetes is therefore categorized as adversely affecting the skeleton.In children and adolescence observations have been more controversial regarding bone mineral content, bone mineral density...

Biographical DetailsS Bechtold-Dalla Pozza is a Consultant Pediatric Endocrinologist working at the Department of Endocrinology and Diabetology of the Dr von Haunersches Kinderspital, Ludwig-Maximilians University, Munich, Germany. She completed her pediatric training at the department of Pediatrics at the University Children’s Hospital, Munich, following a clinical and research fell...

Background: Despite the large amount of studies published on the association of vitamin D deficiency with higher incidence of falls and fractures, the threshold for a sufficient serum 25(OH)D concentration remains subject to a considerable debate. There has also been no clear consensus on the assessment and treatment of vitamin D deficiency.Objective: To examine the prevalence of vitamin D deficiency and/or insufficiency and its impact on calcium/phospha...

Background: Despite the large amount of studies published on the association of vitamin D deficiency with higher incidence of falls and fractures, the threshold for a sufficient serum 25(OH)D concentration remains subject to a considerable debate. There has also been no clear consensus on the assessment and treatment of vitamin D deficiency.Objective: To examine the prevalence of vitamin D deficiency and/or insufficiency and its impact on calcium/phospha...

The aim of the study is to determine whether there is an imbalance between bone formation and bone resorption in nonbacterial osteitis. The osteoclast inhibitor pamidronate has been successfully used in nonbacterial osteitis. It is assumed, that there is any mismatch in the pathophysiology of osteoblasts or osteoclasts. Until now, we have no known publications on bone metabolism in nonbacterial osteitis. We chose osteoprotegerin (OP) and alkaline phosphatase (AP) as markers of...

Objectives: Dysregulation of systemic phosphate homeostasis is often associated with impairment of musculoskeletal tissue function. Many factors such as calcium levels and dysegulated endocrine mechanisms are thought to contribute. Inorganic phosphate and FGF23 have been shown to act via similar signaling pathways in several cell types but we are not aware of any detailed investigations into their effect on the differentiation and viability of skeletal muscle cells. W...

The P2Y2 receptor is a G-protein-coupled receptor and the natural ligands (ATP/UTP) strongly inhibit mineralized bone nodule formation by osteoblasts in vitro. We have earlier shown that overexpression of the P2Y2 receptor in vivo resulted in decreased bone mineral density (BMD), partially due to increased bone resorption, but also decreased formation (detected by serum bone markers and bone histomorphometry).This ...