Bone Abstracts

Osteoclasts are produced by fusion of pre-osteoclasts derived from stem cells of the monocyte/macrophage lineage in the presence of receptor activator of NF-κB ligand (RANKL) produced by osteoblasts. The phytoestrogens; genistein and daidzein, which are isoflavones found in Leguminosae such as soybeans, are currently being investigated for prevention of postmenopausal osteoporosis. Some polyunsaturated fatty acids (PUFAs) have been shown to exert a bone protectiv...

Rooibos (Aspalathus linearis) tea is a refreshing and caffeine-free tea indigenous to the Western Cape regions of South Africa. This tea, which is rich in polyphenols and antioxidants, has shown many beneficial effects in health, however, its anti-osteoclastogenic potential remains unexplored. In this study, the in vitro effects of an aqueous extract of fermented rooibos tea were examined on osteoclast formation and bone resorption in RAW264.7 murine macropha...

Osteoporosis is a growing public health problem. As allies have for preventing physical activity, especially resistance training (RT) and hormone replacement. The aim of this study was to analyze the effect of Raloxifene (RLX) and RT in bone metabolism of rats on their aging period. Wistar rats (14–18 months), sham or ovariectomized (OVX) were treated with RLX (1 mg/kg per day) or saline by gavage and subjected to RT or not. The animals were subjected to RT-oriented pract...

There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually dimorphic pattern in various physiological systems. We tested the hypothesis that abnormal exposure to steroid hormones within a critical developmental period elicits permanent changes on tooth eruption, enamel mineralization, and leptin and corticosterone concentrations in adulthood. Newborn Wistar rats were divided into four groups, two male groups and two...