Bone Abstracts

Ibandronate (IBN), a nitrogen-containing bisphosphonate, and eldecalcitol (ELD), an active vitamin D3 derivative, are used for osteoporosis treatment. Vitamin D3 often used in combination therapies, however, there are no reports on the effects of combined IBN and ELD treatment for osteoporosis.In this study, we examined the effects of combination treatment with IBN and ELD in aged ovariectomized rats. Eight-month-old Wistar-Imamichi...

Purposes: The trabecular bone score (TBS) is an indicator of cancellous bone microstructure obtained from image analysis with lumbar spine dual-energy X-ray absorptiometry (DXA) scans. A decrease in TBS is considered to be a risk factor for vertebral fracture that is independent of BMD. At the same time, it has been reported that, BMD was higher and TBS was lower in women with type 2 diabetes mellitus (DM), and a decreasing TBS is risk factor for fracture. However, the relatio...

We and others have recently showed that patients with type 2 diabetes mellitus (T2DM) have a higher risk for fracture, although they have normal or slightly higher bone mineral density (BMD). These findings suggest that bone fragility in T2DM, which is not defined by BMD, may contribute to fracture risk. Hyperglycemia accelerates the formation of advanced glycation end products (AGEs) and causes diabetic complications. AGEs including pentosidine are also known to cause bone fr...