Bone Abstracts

Awareness of osteoporosis in men is improving, although it remains under-diagnosed and under-treated. Empirical data in men display similarities with data acquired in women, despite pathophysiological differences, which may not be clinically relevant. Men should receive treatment at a similar 10 years fracture probability as in women. Bisphosphonates inhibit osteoclastic bone resorption and are the most widely used drugs in male osteoporosis. The treatment response to oral bis...

Biographical DetailsDr Steven Boyd holds a PhD in Mechanical Engineering, specialized in Biomedical Engineering. He was appointed as a faculty member at the University of Calgary in 2002, and is now a Professor in the Faculty of Medicine (Radiology), and jointly appointed at the Schulich School of Engineering (Mechanical Engineering) and Faculty of Kinesiology. He is a principal investiga...

Patients with improved health understanding have greater autonomy over, and motivation towards, health-related lifestyles. We compared self-perceived fracture risk and 3-year incident fracture rates in postmenopausal women for a range of co-morbid diseases using data from the Global Longitudinal study of Osteoporosis in Women (GLOW).GLOW is an international cohort study involving 723 physician practices across 10 countries in Europe, North America, Austr...

Drug treatment for osteoporosis typically begins with an oral bisphosphonate, regardless of initial BMD or fracture risk and decisions to continue or change treatment are often based on evidence of ‘response’ to treatment based on changes in BMD, bone turnover markers, and occurrence of fractures. Treatment is often continued for fixed periods of time, perhaps stopped for a ‘drug holiday’.This approach differs from preventive therapy ...

High-resolution peripheral quantitative computed tomography (HR-pQCT) provides a non-invasive measure of 3D micro-architecture at a nominal isotropic resolution of 82 μm, and more recently 61 μm with the new generation of scanners. The typical measurement site is at the peripheral skeleton, including the distal radius and distal tibia. The measurement is performed in <2 min now, and radiation dose is low for each scan (~5 μSv). Since it’s introduction i...

Treatment of postmenopausal osteoporosis (PMO) has been traditionally hampered by poor persistence and adherence to short-term (≤1-monthly) medications. The efficacy of 6-monthly (Q6M) denosumab treatment has been proven in clinical trials, but effectiveness will be dependent on persistence and adherence in routine clinical practice. This study is designed to evaluate real-world persistence and adherence to denosumab, and to establish how this is best assessed in long-ac...

Objectives: This study aims to evaluate and compare the preferences of patients and health care professionals for osteoporotic drug treatment.Materials and methods: A discrete choice experiment was conducted among patients and health care professionals (general physicians, rheumatologists, and geriatricians) in Belgium. Participants were asked to choose between two hypothetical unlabelled drug treatments (and an opt-out option) that vary in several attri...

In children with spinal muscular atrophy (SMA): i) describe bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA); ii) examine bone health factors; iii) examine change in BMD over time and pamidronate effect.DXA results, medications, ambulation, 25-OH-Vit D levels, and fracture history were retrospectively reviewed in 14 children (five girls) with SMA. Sites scanned included whole body (WB), lumbar spine (LS), and lateral distal f...

Objectives: Conventional wisdom suggests that bone is most responsive to physical activity during the growing the years, especially the period just before puberty. Few studies have addressed the entire period of adolescence and even fewer have done so using bone imaging techniques to capture structural outcomes which contribute to bone strength. Using a well-defined cohort (The Iowa Bone Development Study, IBDS), this report examined the magnitude and consistency of the associ...

Objective: In girls with Rett syndromeDescribe bone mineral density (BMD) and contributing factors in a cross-section of subjects.Examine serial DXA measures.Examine effect of pamidronate on BMD over time.Methods: We reviewed the clinical course, medications, level of ambulation, 25-OH-Vit D levels, fracture history and DXA results in 13 girls with Rett syndrome. Eight subjects had more...