Bone Abstracts

Objectives: Prospective case-controlled study assessing whether the incidence of loosening of implants in patients undergoing Total Knee Arthroplasty (TKA) is higher among those with Secondary Hyperparathyroidism (SP) at the time of index operation.Material and methods: Caucasian female patients with knee osteoarthritis who underwent TKA between November 2004 and March 2007 were enrolled. Exclusion criteria: endocrinopathies, rheumatoid or secondary arth...

Purpose: Denosumab is a new potent antiresorptive treatment of osteoporosis that can potentially induce a compensatory increase of parathyroid hormone (PTH) levels. We aimed to evaluate the alteration of PTH 1 and 6 months after denosumab’s administration (60 mg) with different regimens of calcium and vitamin D (Ca/D) supplementation, as well as the association of PTH with serum Ca and bone markers.Methods: This was a prospective, multicenter, study...

Skeletal strength, maintained through bone remodelling, is regulated through complex communication networks between bone cells and other tissues including endocrine cells. Bone also functions as an endocrine organ in its own right. The peptide hormone amylin (or Islet Amyloid Polypeptide (IAPP)), has links to both bone and energy metabolism. A member of the calcitonin family of peptides, it is co-secreted with insulin from pancreatic β-cells and is linked with diabetes-as...

Type 2 diabetes and osteoporosis often occur together in postmenopausal women. Sitagliptin is a new drug used in the therapy of type 2 diabetes; it affects incretin system as a result of inhibition of dipeptidyl peptidase-4. So far, the impact of the drug on bone remodeling processes is unknown. The aim of this study was to investigate the effect of sitagliptin on bone growth and remodeling in non-ovariectomized and ovariectomized rats.The experiments we...

Background: Hypophosphataemic rickets (HPR) is an inherited condition of phosphate wasting associated with abnormal bone biochemistry and features of rickets. Most patients respond to treatment with alfacalcidol and oral phosphate. Raised levels of alkaline phosphatase (ALP) and parathyroid hormone (PTH) generally indicate a need for refining treatment, or poor compliance.Presenting problem: We report the case of a 36 week gestation male infant born to c...

Objectives: Anorexia nervosa (AN) is condition of severe low body weight as a result of impaired body image and a fear of gaining weight, often occurring during adolescence, a critical time for bone development. AN has been associated with low bone mass and impaired bone strength. However, many studies have failed to consider body composition, particularly lean mass when assessing bone health. The purpose of this study was to assess if females with AN have an appropriate amoun...

Considering limited information on skeletal system properties in emu (Dromaius novaehollandiae), the aim of this study was to determine morphological and densitometric parameters of tarsometatarsus obtained from adult males (N=6) and females (N=7). The study was performed on birds reared at the Department of Poultry and Ornamental Bird Breeding of Western Pomeranian University of Technology in Szczecin, Poland. Male and female emu were slaughtered to obtain l...

The aim of the study was to evaluate interrelationships between morphometric, densitometric and mechanical properties of femur in ostriches (Struthio camelus). 14-month-old male and female ostriches (N=46) were slaughtered to obtain left femur for analyses. Using quantitative computed tomography (QCT) technique, volumetric bone mineral density (vBMD) of the trabecular (Td) and cortical bone (Cd) were measured. Bone mineral density (BMD) and bone mineral content (BMC) ...

Objective: Autism Spectrum Disorder (ASD) is associated with lower bone mass in children. Physical activity and nutrition influence bone pathophysiology, and differences in these lifestyle factors are observed between children with vs. without ASD; however, whether these factors contribute to bone differences is unknown. We examined if: 1) differences existed in bone mineral density (BMD), content (BMC), or bone geometry in boys with vs without ASD and 2) whether physical acti...

Background: Hypercalcaemia is a risk following stem cell transplant (SCT) for all types of autosomal recessive osteopetrosis (ARO) due to restored osteoclast differentiation. This can be particularly severe in the osteoclast-poor (OP) form involving the tumour necrosis factor receptor superfamily 11A (TNFRSF11A) gene, encoding RANK. Denosumab, a monoclonal antibody blocking RANK activation, has been described for refractory post-SCT hypercalcaemia in two cases. Our case adds n...