Bone Abstracts

Introduction: The RANKL/RANK/OPG system has a key role in bone metabolism. Beyond its role in bone loss, its importance was also documented during inflammation which occurrs in inflammatory bowel disease (IBD). The aim of this study was to investigate the expression of the receptor activator of NF-κB ligand (RANKL) and its receptors RANK as well as its decoy receptor osteoprotegerin (OPG) in the colon during experimantal IBD and following BMP7 or corticosteroid therapy.</...

Background: Orally administered ibandronate is an effective agent in the treatment of postmenopausal osteoporosis. There are only scarce data regarding its use in children with impaired bone health.Objectives: To evaluate the effect of oral ibandronate on bone health in osteoporotic children and adolescents.Patients, materials and methods: We enrolled six patients (all boys; mean age 15.7±3.8 years; range 8–18 years) with...

Background: Hypocalcaemia can be manifested by paresthesia, muscle cramps, muscle weakness, syncope, convulsions and even severe psychomotor retardation. Suchs symptoms can be initially considered as signs of epilepsy. Fahr’s disease is neurological disorder with neuropsychic changes and convulsions. Fahr’s disease is characterized by central nervous system calcifications caused by mutations in SLC20A2 gene, encoding sodium-dependent phosphate transporter 2 (PiT-2) t...

Objectives: To evaluate the effect of oral ibandronate on bone health in osteoporotic children and adolescents, as there are only scarce data regarding its use in pediatric population.Patients, materials, methods: We enrolled seven patients (six boys; one girl; mean age 15.3±3.8 years; range 8–18 years) with low bone mineral density (BMD) (mean 0.746±0.141 g/cm2; i.e. −3.3±1.5 S.D. z-score) and...

Background: Treatment with orally administered ibandronate is an effective way to increase bone mineral density (BMD) and reduce fracture rate in post-menopausal women and in men with osteoporosis. There are only very few reports concerning ibandronate therapy in children/adolescents, and in patients with osteogenesis imperfecta (OI), as bisphosphonates are off-label drugs in pediatrics.Case presentation: We present two patients with OI type I (14 year o...

Cadmium (Cd) is regarded as a risk factor for various bone diseases in humans and experimental animals. To compare effects of different routes of Cd administration on femoral bone structure, ten 4-month-old male Wistar rats (group A) were injected intraperitoneally with a single dose of 2 mg CdCl2/kg body weight and killed 36 h after Cd had been injected. Ten 1-month-old male rats (group B) were dosed with a daily Cd intake of 30 mg CdCl2/l in drinking wa...

Background: We have previously shown that MLO-Y4 osteocytes express a number of P2 receptors, respond to a broad range of nucleotides (e.g. UTP) by increasing intracellular calcium concentration and release ATP upon both mechanical and UTP stimulation. The aim of this study therefore is to investigate how the osteocytes release ATP and whether there is a difference in release pathway depending on the type of stimulus.Methods: ATP release was investigated...

The aim was to explore whether osteoporosis in humans influences the morphological status of the cartilage and subchondral bone, and relationship between macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone. Femoral heads were obtained from 68 patients with osteoporosis (OP) and hip OA (OP, n=56; OA, n=12) during hip surgery. Evaluation of the cartilage degeneration was done by Mankin g...

Osteoporosis and fragility fractures correlated, are a major clinical problem in older women and men and a major public health problem worldwide. As the population ages, the incidence of osteoporotic fractures is increasing. These fractures are associated with higher health care costs, physical disability, impaired quality of life, and increased mortality.Aim: evaluation of the frequency, type and age of onset of fragility fractures in 110 centenarians (...

Deceased donor kidneys are exposed to cold ischemic insult, which makes them particularly susceptible to the effects of cold ischemic injury during hypothermic preservation resulting in high rates of delayed graft function. Although cold storage reduces cellular oxygen demand, ischemia causes the rapid depletion of adenosine triphosphate and accumulation of toxic substances leading to cell death. BMP-7 is a valuable reagent in a field of tissue regeneration and preservation un...