Bone Abstracts

Objective: Transfusion dependent thalassemia (TM) patients have routinely been placed on vitamin D supplementation due to their increased risk of osteoporosis, as well as their high rates of vitamin D deficiency (serum 25 hydroxyvitamin D (25-OHD) <11 ng/ml) and insufficiency (25-OHD <30 ng/ml). Furthermore, recent studies have linked 25-OHD levels to hypercalciuria and nephrolithiasis in TM. The objective of this study is to determine the effect of vitamin D supplemen...

The regeneration of traumatized, damaged or lost bone is still a major clinical and socio-economical problem. Bone-tissue engineering approaches involve culturing mesenchymal stem cells (MSCs) on scaffolds, in order to create a 3D microenvironment in which MSCs are able to generate functional tissues and regulate foreign body reaction to implanted construct. Excessive or non-resolving inflammation, characterized by the presence of monocytes, macrophages and giant cells, makes ...

Bone-tissue engineering approaches involve culturing mesenchymal stem cells (MSCs) on 3D scaffolds designed to mimic the composition, structure, and biomechanics of the native bone matrix. One of the key challenges in bone–tissue engineering is to understand the host response to implantable engineered constructs. Macrophages play an important role in fracture healing and tissue repair and are mainly involved in the inflammatory response at the early stage upon scaffold im...

Adiponectin has recently been shown to influence skeletal metabolism. Over-expression of adiponectin gene suppresses bone resorption and increases trabecular bone mass. Bone marrow stromal cells from adiponectin-null mice had reduced mineralized nodule formation ability compared with wild type mice. Adiponectin, signalling via the adiponectin receptor 1 (AdipoR1) stimulates osteoblast differentiation and inhibits osteoclastogenesis. We have shown that the globular for...