Bone Abstracts

Background: Bone metabolic disorders, such as osteoarthritis (OA), osteopenia and osteoporosis have been associated to iron overload, both in humans and animal models. In the case of hereditary hemochromatosis (HH), arthropathy represents one of the most prevalent and disabling symptoms. This work aims at investigating the roles of HH-related HFE mutation and iron accumulation on chondrocyte metabolism.Materials and methods: Primary cultures of articular...

Introduction: Most studies to date have focus on the effect of exercise interventions on bone remodeling. Furthermore, inflammation has been associated with those critical for bone physiology and remodeling. However, investigations analyzing the relationship between objective physical activity and bone metabolism and inflammatory markers and the potential interactions with BMD and body composition in older men are limited, which is the aim of the present study.<p class="ab...

Aims: To describe different multinucleated giant cell phenotypes and their associations with synovitis in people with rheumatoid arthritis (RA) or osteoarthritis (OA), and in an experimental model of chronic arthritis.Material and methods: A cross-sectional comparative study was performed on samples of knee synovia from age-matched patients with RA, OA, or non-arthritic post mortem (PM) controls. OA synovia were stratified by histological inflammation gr...

Introduction: Clinical practice guidelines recommend a daily intake of calcium of 1-1, 5 g for posmenopausical osteoporosis. However, giving the possible adverse effects of calcium supplements, their use remains controversial.Aims: Validate the dietary assessment of calcium. Evaluate the degree of compliance of the medical advice and discuss the adequacy of prescribing calcium supplements.Patients and methods: Sample cohort compris...

Introduction: Osteocytes play a major role in the bone remodelling unit (BRU). Thus, we hypothesize that mitochondrial bioenergetics impairment and mitochondrial/peroxisomal fatty acid β-oxidation unbalance is a cause of osteocytes metabolic decline during 17β-estradiol (E2) reduction. E2 and a phytochemical substitute, coumestrol (COU) were used (30 mg/kg during 24 h in ovariectomized rats in order to compare bone loss with sham-operated animal...

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The aims of this study were to establish the prevalence of the high bone mass (HBM) phenotype in a cohort of Spanish postmenapausal women (BARCOS); to determine whether any of the HBM cases carry LRP5 or DKK1 mutations; to test the hypothesis of an inverse correlation between the number of common variant risk alleles and HBM; and to characterize the expression of osteoblast-specific and Wnt pathway genes in primary osteoblast RNA samples from two HBM cases.</...

Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotype variability. The aim of this study was to identify osteoporosis-related SNPs by affecting the expression levels of mature microRNAs.The first approach was to perform an association analysis of putative functional SNPs located in pri-miRNA sequences of bone-related microRNAs with the lumbar spine and femoral neck (FN) bone mineral den...