Bone Abstracts

Beside the bone mass, structural changes are important determinants of the bone strength. Patients with osteoarthritis (OA) seem protected against femoral neck (FN) fracture. When compared to osteoporosis, FN in OA are characterized by a higher bone mass and a better trabecular microarchitecture (Blain et al., 2008, Boutroy et al., 2011). The presence of microcracks is one of the determinants of the bone strength. The aim of this study was to evaluate the mic...

Osteoclast presents a central role in several inflammatory diseases that are associated to bone destruction. This condition results from increased osteoclastic bone resorption and/or decreased bone formation. Fluoride (F) is widely consumed in the drinking water due to its anticariogenic effect and has been shown to modulate in vivo bone metabolism in a strain-specific dependent manner. It enhances bone formation in 129P3/J mice but not in A/J mice. However, its effec...

Osteoporosis is a chronic disease with a high prevalence in older adults. There is evidence that statins have some beneficial effects on bone metabolism. Although the trial reports are ambiguous, it is now accepted that statins block the osteoclast differentiation inhibiting to some extent bone resorption. Our aim was to evaluate the effects of a statin in an animal model, which was induced to osteoporosis by glucocorticoids and then treated with atorvastatin. The experimental...

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Emerging evidence suggests that miRNAs (miR) can modulate a complex gene network in a cell-intrinsic and non-cell autonomous manner. We previously identified by transcriptomic analysis miR-192 to be heavily downregulated in different highly metastatic subpopulations (HMS) isolated from bone metastases in a lung cancer mice model, but its mechanistic contribution to the prometastatic activity remains unknown.To delineate the pleiotropic functions elicited...