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Interleukin-6 (IL-6) plays an important role in bone metabolism and regulates fracture healing in a presently unknown process. In the fracture callus IL-6 expression is biphasic; it peaks during the inflammatory phase and again during intramembranous and endochondral ossification (Ai-Aql et al. 2008). Few studies using IL-6 knockout mice indicate that IL-6 might be crucial for bone healing (Yang et al. 2007). However, a generalized IL-6 knockout induces multi...

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ba0005p55 | Bone development/growth and fracture repair | ECTS2016

Calcium and vitamin-D supplementation post-trauma improves bone healing and decreases posttraumatic bone resorption in an osteoporotic mouse model

Heidler Verena , Haffner-Luntzer Melanie , Prystaz Katja , Kroner Jochen , Schinke Thorsten , Amling Michael , Ignatius Anita

Chronic calcium- and vitamin-D-deficiencies are crucial risk factors for osteoporosis. However, their significance for fracture healing is still poorly investigated, despite the clinical evidence that osteoporotic bone healing is disturbed. This study addressed the important question, whether chronic deprivation of calcium and vitamin D compromises bone repair and if this could be rescued by a supplementation post-trauma. Because clinical hints suggest that a fracture induces ...

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ba0005p59 | Bone development/growth and fracture repair | ECTS2016

Midkine is involved in the pathogenesis of delayed osteoporotic fracture healing after ovariectomy in mice

Haffner-Luntzer Melanie , Kemmler Julia , Heidler Verena , Prystaz Katja , Schinke Thorsten , Amling Michael , Ignatius Anita , Liedert Astrid

Previous studies demonstrated a negative influence of the growth- and differentiation factor midkine (MDK) on bone formation during bone remodeling and fracture healing. Additionally, MDK-deficiency protected mice from a loss of trabecular bone mass after ovariectomy (OVX). Therefore, we hypothesized that MDK may also be involved in the pathogenesis of delayed, osteoporotic fracture healing after OVX in mice. Thus, we analyzed the expression of MDK during bone regeneration and...

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ePoster Contact

ba0006p133 | (1) | ICCBH2017

Long term treatment with intravenous pamidronate in two children with severe form of juvenile Paget's disease

Verfurth Katja , Hovel Matthias , Schundeln Michael , Bauer Jens , Grasemann Corinna

Presenting problem: Severe forms of juvenile Pagets Syndrome (JPD) result in extreme bone turnover, necessitating long-term treatment with anti-resorptive drugs to control for bone pain and modeling of bones.Objective: To report clinical and biochemical effects of intravenous treatment with Pamidronate in two children with severe forms of JPD over a time period of 3 and 9 years, respectively. Treatment was commenced at 12 months and 3 years of age,...

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ba0005cabs.oc4.5 | Oral Communications | ECTS2016

New models of breast and lung cancer bone metastases for preclinical efficacy testing

Suominen Mari I. , Hagemann Urs B. , Konkol Yvonne , Bernoulli Jenni , Fagerlund Katja M. , Bjerke Roger M. , Karlsson Jenny , Halleen Jussi M. , Cuthbertson Alan

In advanced ER+ve breast cancer, the propensity of bone involvement is 85%. Similarly in advanced lung cancer, 3040% of patients develop bone metastases, and as recent advances in lung cancer therapies improve survival, the number of patients living with bone metastases is expected to increase. At the same time there is a paucity of especially ER+ and osteoblastic animal models available. We present herein the development of four mouse models of breast and lung cancer su...

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ba0005lb9 | (1) | ECTS2016

First X-linked form of osteogenesis imperfecta, caused by mutations in MBTPS2, demonstrates a fundamental role for regulated intramembrane proteolysis in normal bone formation

Lindert Uschi , Cabral Wayne , Ausavarat Surasawadee , Tongkobpetch Siraprapa , Ludin Katja , Barnes Aileen , Yeetong Patra , Weis Maryann , Krabichler Birgit , Makareeva Elena , Janecke Andreas , Leikin Sergey , Rothlisberger Benno , Rohrback Marianne , Kennerknecht Ingo , Eyre David , Suphapeetiporn Kanya , Giunta Cecilia , Marini Joan , Shotelersuk Vorasuk

Osteogenesis imperfecta (OI) is a heritable bone dysplasia with collagen-related defects. Dominantly inherited OI is caused by structural defects in type I collagen or IFITM5, while recessive forms are caused by deficiency of proteins that interact with collagen for modification, folding or cross-linking. We have identified the first X-linked form of OI, caused by a defect in regulated intramembrane proteolysis (RIP). One type of RIP involves sequential cleavage of regulatory ...

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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...

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Bone Abstracts

Role of interleukin-6 in the early and late fracture healing phase

Calcium and vitamin-D supplementation post-trauma improves bone healing and decreases posttraumatic bone resorption in an osteoporotic mouse model

Midkine is involved in the pathogenesis of delayed osteoporotic fracture healing after ovariectomy in mice

Long term treatment with intravenous pamidronate in two children with severe form of juvenile Paget's disease

New models of breast and lung cancer bone metastases for preclinical efficacy testing

First X-linked form of osteogenesis imperfecta, caused by mutations in MBTPS2, demonstrates a fundamental role for regulated intramembrane proteolysis in normal bone formation

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