Bone Abstracts

Patients with Duchenne muscular dystrophy (DMD) carry a mutation in the dystrophin gene that leads to progressive muscle degeneration. In addition, DMD patients develop low bone mass especially in long bones and have high incidence of fractures. The underlying mechanisms for decreased bone mass remain unclear but muscle weakness and increased IL6 levels may play a role. Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and strength...

Data on the prevalence of vitamin D deficiency/insufficiency in children with haematological malignancies (HM) in Sweden are scarce. Our studies indicate that one third of children with HM had vitamin deficiency/insufficiency already at the time of diagnosis. In this study, we aimed to investigate the impact of season and age at HM onset on vitamin D status by analysing 25(OH)D levels in two different age groups: children ≤6 years of age, and children >6 years of age...