Bone Abstracts

Osteoporosis is a chronic disease with a high prevalence in older adults. There is evidence that statins have some beneficial effects on bone metabolism. Although the trial reports are ambiguous, it is now accepted that statins block the osteoclast differentiation inhibiting to some extent bone resorption. Our aim was to evaluate the effects of a statin in an animal model, which was induced to osteoporosis by glucocorticoids and then treated with atorvastatin. The experimental...

The body mass index has been regarded as a risk predictor factor for fractures, and in some prospective cohort studies it has been suggested that obesity could be a protective factor for hip fractures in adults.The present study aimed to investigate whether body mass index is related to the fracture risk when individuals had sideways falls in Mexican patients. We analyzed files from 448 patients, which checked in at Orthopedics and Traumatology Service i...

It is widely accepted that the “gold” standard method for diagnosis of osteoporosis is dual energy X-ray absorptiometry, to measure bone mineral content and bone mineral density (BMD). However in the last decades other less harmful and cheaper methods were developed. Among them bioelectrical impedance analysis (BIA) is one of most commonly used and is used in analysis of body composition as well. On its side, quantitative ultrasound (QUS) is a noninvasive method of e...

Vitamin D plays an important role for bone health, and is associated to the risk of osteoporosis development.The aim of the present work was to determine the association between serum vitamin D concentration and the bone mineral density (BMD) in post-menopausal women living in a Mexican rural community (this study was approved by the Institutional Ethics Committee). The BMD was assessed by ultrasound and vitamin D was evaluated using a specific immunoass...

There is some evidence that caffeine consumption has effects on bone mineral metabolism, however the reports in this regard show some ambiguity. Being this compound one of the most popular for human consumption in the world, we analyzed the effects of soluble caffeine subcutaneous administration on serum osteocalcin and serum bone alkaline phosphatase (bALP) in Wistar male rats (weighting 200–250 g). Variable doses were used (30, 75, 150 mg/kg), during 30 days. The animal...