Bone Abstracts

Sarcopenia has been indicated as one of the important markers of frailty among the elderly. This study aims to evaluate mortality risk among Japanese elderly persons with sarcopenia, taking into account lifestyle and physical factors.From among a population-based community cohort, the Adult Health Study conducted at RERF, 1880 subjects (626 men and 1 254 women) aged 47–95 years old were enrolled in a prospective and longitudinal cohort study in Hiro...

Minodronate has been reported to increase bone mineral density (BMD) and reduce fracture risk. The purpose of this study was to clarify the effect of minodronate on the three-dimensional vertebral microarchitecture in vivo.Minodronate-treated osteoporosis female patients (n=9) and non-treated age-matched historical control (n=5) were retrospectively evaluated. After areal BMD (aBMD) evaluation by DXA, 3rd lumbar spine was scann...

We previously reported that interleukin (IL)-11 plays an important role in the mechanical stress and PTH-induced stimulation of osteoblast differentiation and bone formation. Mechanical stress and PTH enhance IL-11 gene promoter activity and increase IL-11 expression. Increased IL-11 down-regulates dikkopf 1/2 (Dkk1/2) expression and stimulates canonical Wnt signaling, which enhances osteoblast differentiation. The present study was undertaken to clarify the physiological role...