Bone Abstracts

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Abaloparatide (ABL) is a novel analog of hPTHrP (1–34) in clinical development for treatment of osteoporosis. This study evaluated the long-term effects of ABL on BMD and bone strength in aged osteopenic, ovariectomized (OVX) monkeys. Four groups of ≥9-year-old female cynomolgus monkeys underwent OVX and one group underwent Sham surgery. After a 9-month bone depletion period, increases in bone markers and decreases in BMD by DXA and pQCT were observed for OVX groups...

Objectives: Clinicians practicing in long-term care (LTC) face unique challenges caring for frail elderly individuals including multiple co-morbidities, polypharmacy, and end of life care, and practice guidelines typically do not address this population. Guidance regarding the management of osteoporosis and fracture prevention in LTC, a high-risk population, is needed.Materials and methods: A survey of LTC physicians informed key questions and outcomes, ...

Aim: The aim of this study was to assess the calcium daily food intake in Lebanese women living in South Lebanon, an under privileged area.Subjects and methods: Assessment of calcium food intake was performed with a validated questionnaire in 290 female patients attending clinics in two main referral health centers in South Lebanon.Results: The mean age of patients was 54.76 years and the mean BMI was 30.07 kg/sqm (S.D.</sma...

The oim/oim mouse resembles type III OI. Our study mimics clinical questions: is RANK-Fc as efficacious as ALN in reducing fracture number? Is RANK-Fc safe to administer to children? Is there any advantage to receiving RANK-Fc treatment post adolescence, following no treatment or ALN treatment from infancy through adolescence?All animal work was done under an IACUC-approval. Mice – n=200, WT or oim/oim. Treatment spanned a...

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Aims and background: Osteoporosis is a growing public health problem in developing countries. Awareness can lead to reduction in the incidence of the disease and consequently the fragility fractures.Osteoporosis knowledge is an important contributor to improving management and treatment of patients. The aim of this study was to measure osteoporosis knowledge among Lebanese physicians.Subjects and methods: Representative random samp...

Several studies have shown a higher mortality after hip fracture but the reasons and the duration of the excess risk is not well understood. We aimed to determine whether there exists a higher mortality after hip fracture when controlling for genetic constitution, environmental and life-style risk factors, and comorbidity. All 286 identical Swedish twin pairs discordant for hip fracture (1972–2010) were identified by use of the National patient register and the Swedish tw...

Objective: The purpose of this study was to determine whether osteogenesis imperfecta (OI) patients entering adulthood should continue with bisphosphonate therapy or would benefit from switching to a RANKL blockade therapy. To address this question, we used a mouse model of type III OI.Methods: Animal studies were performed under IACUC approval. OI (oim/oim) and wild-type (WT) mice were treated from 2–26 weeks with i) saline; ii) alendronat...

Objective: The purpose of this ongoing study was to determine whether osteogenesis imperfecta (OI) patients entering adulthood should continue with bisphosphonate therapy or would benefit from switching to a RANKL blockade therapy. To address this question, we used a mouse model of type-III OI.Methods: Under IACUC-approval, +/+ and oim/oim mice were treated from 2–26 weeks (n=20/treatment/genotype) with either 1) saline 24 weeks; 2...