Bone Abstracts

Using ovariectomized rats as an animal model of postmenopausal women, we examined the causal relationship between fluoride (F) exposure and the high risk of development of osteoporosis. In order to obtain the estrogen (Es) deficient animals, 5-week-old Sprague–Dawley rats, which were overiectomized at 3- and the 5-week-old female rats without ovariectomy were purchased. The overiectomized rats were divided into two groups: the Es deficient, and the combination of Es defic...

The purpose of the present study is to examine the relationship between the formation and composition of incremental lines in tooth dentin and the role of melatonin through histological and analytical studies. In this experiment, 5, 6 and 7 day old SD rats were used. These rats were divided into three groups: i) a control group (0.5% alcohol content drinking water); ii) a low concentration group (0.5% alcohol+20 μg/ml melatonin content drinking water); and iii) a high con...

Introduction: Recessive osteogenesis imperfecta (OI) is caused by mutations in genes encoding proteins involved in post-translational interactions with type I collagen. Types VII–IX OI involve defects in the collagen prolyl 3-hydroxylation complex, which modifies α1(I)Pro986. PPIB encodes CyPB, a complex component with PPIase activity and the major isomerase facilitating collagen folding. We investigated the role of CyPB in collagen post-translational modifications a...

Objective: To examine the efficacy and safety of direct administration of zoledronate acid (ZOL) on local osteoporotic lesion of ovariectomized rats.Methods: Six weeks later after ovariectomy, 16 6-month-old female S.D. rats were divided into the two groups with no differences of body weight and BMD of the proximal tibia. In the group L, 50 μl ZOL at a dose of 67 μg/kg were locally injected into the bone marrow between the two dr...

Backgrounds: Ossification of the posterior longitudinal ligament (OPLL) is characterized by pathological ectopic ossification of the posterior longitudinal ligament. Development of OPLL induces compression myelopathy or radiculopathy by spinal stenosis and the loss of spinal flexibility by ankylosing spinal hyperosteosis (ASH). Although the etiology of OPLL has not been fully elucidated, systemic and local bone formation factors may play a role in the pathogenesis of OPLL. The...

The effects of neonatal thymectomy, at 3 days of age, on skeletal sexual dimorphism and bone quality during the development were examined in male and female Wistar rats. Rats were euthanized at 20, 40, or 120 postnatal days and femurs were collected. The Biomechanical compression test was used to evaluate bone breaking strength, energy-to-fracture, and extrinsic stiffness. During the prepubertal period, the neonatal thymectomy increases extrinsic stiffness of bone tissue signi...