Bone Abstracts

The coupling of bone formation to bone resorption during treatment of postmenopausal osteoporosis with antiresorbers might be related to changes in Wnt/β-catenin signalling. We compared the effects of two bisphosphonate treatments on two Wnt inhibitors sclerostin (SOST) and Dickkopf-related protein 1 (DKK1). The study population included 72 women with postmenopausal osteoporosis participating simultaneously in two multicenter, placebo controlled trials. The patients were ...

Context: Anorexia nervosa (AN) occurs predominantly in females, most frequently during adolescence and it is generally associated with amenorrhoea. AN increases the risk for impaired bone health and for low bone mineral density (BMD) by a mechanism which has not been yet well defined.Objective: The study purpose was to further characterize bone metabolism in AN with amenorrhoea, and so with oestrogen deficiencyDesign: AN patients w...

Patients with improved health understanding have greater autonomy over, and motivation towards, health-related lifestyles. We compared self-perceived fracture risk and 3-year incident fracture rates in postmenopausal women for a range of co-morbid diseases using data from the Global Longitudinal study of Osteoporosis in Women (GLOW).GLOW is an international cohort study involving 723 physician practices across 10 countries in Europe, North America, Austr...

Zoledronic acid has been shown to reduce the risk of fractures and improve bone mineral density (BMD) in osteoporosis vs placebo. This study compared changes in BMD in patients with osteoporosis treated with zoledronic acid vs alendronate. BMD at the lumbar spine and total hip pre- and post-bisphosphonate were recorded for 65 patients with osteoporosis (T score ≤−2.5) from retrospective analysis of DEXA scans. 35 patients received annual 5 mg IV zoledronic...

Osteoarthritis (OA) and osteoporosis (OP) are two diseases characterized by the alteration of bone quality, that affect mainly elderly people reducing their quality of life. Although an inverse relationship between has been shown by some studies, other reports supported the co-existence of these pathologies. In this study we combined clinical and structural features to clarify the relationship between OA and OP.Among all the patients who underwent a tota...

Bone is the primary site of metastasis for breast cancer, which leads mainly to osteolytic lesions, Cancer cells can expand into the bone for their ability to ‘dialogue’ with resident cells, interfering with the physiological processes of bone turnover. In this study, a large-scale analysis comparing gene expression of biopsies of bone and visceral metastases from human breast cancer patients showed that the receptor (G protein-coupled) activity modifying protein-2 (...

Introduction: A retrospective analysis we previously performed on post-menopausal women showed that the addition of inulin (3 g) and soy isoflavones (40 mg) to daily calcium (500 mg) and vitamin D3 (300 UI) supplementation was able to increase calcium absorption by 60%, while reducing circulating parathormone and leaving vitamin D3 levels unchanged. Therefore, we tested whether such a mixture could affect also bone metabolism.Method...

Objective: In many traumatic or pathological conditions, bone turnover is low and osteoclast activity is reduced or abolished. We developed innovative hydroxyapatite (HA) scaffolds carrying RANKL expressing cells with the aim of supporting bone resorption when this is defective. Membrane-bound (m)RANKL is cleaved into soluble (s)RANKL by MMP14. We hypothesized that the osteoclastogenic potential of RANKL-producing cells could be improved if they were seeded on scaffolds engine...

Background and objective: Data concerning the incidence of fractures in Italy have been displayed since year 2000 by analysing hospital discharge records (HDRs). However, the influence of seasonal and environmental factors on fracture events in the Italian population has not yet been assessed.Methods: We have analyzed HDRs for primary diagnosis of hip, vertebral, forearm, humeral and knee fractures in Italy from year 2007 to 2009. Inferential statistics ...

Introduction: Currently, osteoporosis is mainly diagnosed through dual-enargy X-ray absorptiometry (DXA). However, DXA cannot be used for early diagnoses through population mass screenings because of issues related to ionizing radiation employment. Aim of this study is to perform a preliminary clinical validation of a new ultrasound (US)-based method for vertebral densitometry.Methods: A total of 270 women were included in this study according to the fol...