Bone Abstracts

Biographical DetailsDr Marie Gdalevitch completed both her medical and orthopedic surgery degrees at McGill University. Following her residency, Dr M Gdalevitch pursued her first fellowship in limb lengthening and deformity correction at the International Center for Limb Lengthening in Baltimore, Maryland. Dr M Gdalevitch then embarked on her second fellowship in pediatric orthopedics and...

Aim: The aim of the study was to investigate the relationship between gut hormones and bone re-modeling and intestinal growth by measuring meal stimulated changes in hormones and bone markers in blood samples collected from patients before and after gastric bypass (GBP).Methods: Eighteen patients (12 females and 6 males) were included in the study, approved by the Municipal Ethical Committee of Copenhagen. All subjects were studied before surgery (~2 wee...

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Introduction: Osteoporotic fractures are known to be costly to society but estimates tend to be based on small scale prospective studies. In the following we report national data for healthcare costs due to fractures in patients with osteoporosis.Study population and methods: All Danish residents aged 35+, mean age 70.5 years, 13% men, 27.3% prior major osteoporotic fracture, who began bisphosphonates for osteoporosis between 1/1997 and 12/2002 (n</e...

Objectives: To confirm effect of intravenous treatment with ibandronate every three months in common population of postmenopausal women.Methods: Patients with postmenopausal osteoporosis, who fulfil ACR criteria for postmenopausal osteoporosis and were treated with intravenous ibandronate for two years, underwent DEXA examination.Results: A 50 women suffering from postmenopausal osteoporosis were treated with ibandronate i.v. every...

The objectives of this talk are to discuss the assessment, management, and operative indications of upper limb deformities in osteogenesis imperfecta (OI). The indications for operative treatment of upper limb deformities have evolved with the advent of improved medical treatment (bisphosphonates) and long bone rodding in the lower extremities. Long bone rodding in the lower extremities has become standard treatment in OI. However, upper limb deformities are less commonly trea...

Introduction: Communication of absolute and relative risks is challenging despite the development of tools to quickly derive absolute fracture risk estimates from risk factors with or without BMD. We speculated that back-transformation of risks to a risk age could make for a clearer message and at the same time increase agreement between risk algorithms.Results: The algorithms differed less in estimated bone health age than in percent risk. A 60 years ol...

Bone pain is a common symptom of both malignant and non-malignant bone disease. Bone pain is often the first sign of metastatic spread in patients suffering from breast, lung or prostate cancer. Cancer-induced bone pain is one of the most difficult of all persistent pain states to fully control, and it severely affects the quality of life of the patients.Bone pain is also a common symptom of non-malignant metabolic bone diseases such as osteomalacia, fib...

The pathophysiology of secondary hyperparathyroidism (II HPT) in the absence of renal disease is mainly due to lack of vitamin D, calcium deficiency being extremely rare. In case of chronic kidney disease (CKD), phosphate retention and increase in secretion of FGF23 by bone are among the earliest factors associated with II HPT occurrence. Then, the deficit in calcitriol synthesis induces lack of calcium intestinal absorption which worsens II HPT. As renal function declines, th...

Blood vessels and bone display spatial and functional relationships. While the coupling of angiogenesis to bone formation during modeling situations is well documented, the vessels roles in bone remodeling, although widely acknowledged, remain poorly explored. In order to image and quantify the bone vessel network in rodents, we contrasted the vascular bed with barium sulfate, followed by histology or either conventional or synchrotron radiation micro-computed tomography. We s...